Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 1144496..1145031 | Replicon | plasmid pSymA |
| Accession | NZ_CP085527 | ||
| Organism | Sinorhizobium meliloti strain L6-AK89 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | LJD24_RS24470 | Protein ID | WP_014989489.1 |
| Coordinates | 1144756..1145031 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A2N8JT21 |
| Locus tag | LJD24_RS24465 | Protein ID | WP_013845222.1 |
| Coordinates | 1144496..1144756 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJD24_RS24430 (LJD24_24430) | 1139511..1139900 | - | 390 | WP_017269045.1 | very short patch repair endonuclease | - |
| LJD24_RS24435 (LJD24_24435) | 1140113..1141183 | + | 1071 | WP_017269044.1 | DUF262 domain-containing protein | - |
| LJD24_RS24440 (LJD24_24440) | 1141173..1141838 | + | 666 | WP_017269043.1 | MAE_28990/MAE_18760 family HEPN-like nuclease | - |
| LJD24_RS24445 (LJD24_24445) | 1141826..1142995 | - | 1170 | WP_162145862.1 | DNA cytosine methyltransferase | - |
| LJD24_RS24450 (LJD24_24450) | 1143466..1143708 | + | 243 | WP_013845224.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| LJD24_RS24455 (LJD24_24455) | 1143705..1144124 | + | 420 | WP_013845223.1 | type II toxin-antitoxin system VapC family toxin | - |
| LJD24_RS24460 (LJD24_24460) | 1144132..1144341 | + | 210 | Protein_1123 | transposase | - |
| LJD24_RS24465 (LJD24_24465) | 1144496..1144756 | + | 261 | WP_013845222.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| LJD24_RS24470 (LJD24_24470) | 1144756..1145031 | + | 276 | WP_014989489.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LJD24_RS24475 (LJD24_24475) | 1145080..1146234 | + | 1155 | WP_017271252.1 | site-specific integrase | - |
| LJD24_RS24480 (LJD24_24480) | 1146283..1146582 | - | 300 | WP_017271251.1 | hypothetical protein | - |
| LJD24_RS24485 (LJD24_24485) | 1147085..1147522 | - | 438 | WP_013845218.1 | VOC family protein | - |
| LJD24_RS24490 (LJD24_24490) | 1148159..1148540 | + | 382 | Protein_1129 | integrase | - |
| LJD24_RS24495 (LJD24_24495) | 1148696..1149643 | - | 948 | WP_013845217.1 | LysR substrate-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | htpB | 1..1217792 | 1217792 | |
| - | flank | IS/Tn | - | - | 1144114..1144341 | 227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10895.46 Da Isoelectric Point: 9.9707
>T220839 WP_014989489.1 NZ_CP085527:1144756-1145031 [Sinorhizobium meliloti]
MKLEWTSKAVADLGRLYDFLAPVNRQAAARTVQSWTSAPARLLEQPRIGERLEEFDPREVRRILVGHYEIRYEIRQSTIY
VLRLWHTREDR
MKLEWTSKAVADLGRLYDFLAPVNRQAAARTVQSWTSAPARLLEQPRIGERLEEFDPREVRRILVGHYEIRYEIRQSTIY
VLRLWHTREDR
Download Length: 276 bp
>T220839 NZ_CP117298:719206-719613 [Mycobacterium tuberculosis variant bovis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9652.01 Da Isoelectric Point: 4.8182
>AT220839 WP_013845222.1 NZ_CP085527:1144496-1144756 [Sinorhizobium meliloti]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDAGRVIDHQAVQAWADSLDSDK
PLSLPL
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDAGRVIDHQAVQAWADSLDSDK
PLSLPL
Download Length: 261 bp
>AT220839 NZ_CP117298:718949-719209 [Mycobacterium tuberculosis variant bovis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|