Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 194769..195304 Replicon plasmid pCpl
Accession NZ_CP085526
Organism Sinorhizobium meliloti strain L6-AK89

Toxin (Protein)


Gene name relE Uniprot ID A0A6G1WU13
Locus tag LJD24_RS18065 Protein ID WP_024325581.1
Coordinates 195029..195304 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2N8JT21
Locus tag LJD24_RS18060 Protein ID WP_013845222.1
Coordinates 194769..195029 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJD24_RS18030 (LJD24_18030) 190120..191031 - 912 WP_026031090.1 FAD-dependent thymidylate synthase -
LJD24_RS18035 (LJD24_18035) 191212..192151 - 940 Protein_196 DUF1612 domain-containing protein -
LJD24_RS18040 (LJD24_18040) 192306..192692 + 387 WP_227692141.1 cell division protein ZapB -
LJD24_RS18045 (LJD24_18045) 192689..193231 + 543 WP_227692142.1 hypothetical protein -
LJD24_RS18050 (LJD24_18050) 193228..193998 + 771 WP_227692143.1 transposase -
LJD24_RS18055 (LJD24_18055) 194000..194320 - 321 WP_017270735.1 hypothetical protein -
LJD24_RS18060 (LJD24_18060) 194769..195029 + 261 WP_013845222.1 ribbon-helix-helix domain-containing protein Antitoxin
LJD24_RS18065 (LJD24_18065) 195029..195304 + 276 WP_024325581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJD24_RS18070 (LJD24_18070) 195353..196421 + 1069 Protein_203 tyrosine-type recombinase/integrase -
LJD24_RS18075 (LJD24_18075) 196584..196808 - 225 WP_227692144.1 hypothetical protein -
LJD24_RS18080 (LJD24_18080) 196878..197147 + 270 WP_017270052.1 hypothetical protein -
LJD24_RS18085 (LJD24_18085) 197232..197828 + 597 WP_012881178.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LJD24_RS18090 (LJD24_18090) 198555..199765 - 1211 Protein_207 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - htpB 1..349886 349886


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10822.40 Da        Isoelectric Point: 9.9707

>T220834 WP_024325581.1 NZ_CP085526:195029-195304 [Sinorhizobium meliloti]
MKLEWTSKAVADLGRLYDFLAPVNRQAAARTVQSLTSAPARLLEQPRIGERLEEFDPREVRRILVGHYEIRYEIRQSTIY
VLRLWHTREDR

Download         Length: 276 bp

>T220834 NZ_CP117298:c696154-695762 [Mycobacterium tuberculosis variant bovis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9652.01 Da        Isoelectric Point: 4.8182

>AT220834 WP_013845222.1 NZ_CP085526:194769-195029 [Sinorhizobium meliloti]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDAGRVIDHQAVQAWADSLDSDK
PLSLPL

Download         Length: 261 bp

>AT220834 NZ_CP117298:c696408-696151 [Mycobacterium tuberculosis variant bovis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G1WU13

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8JT21

References