220828

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2178005..2178659 Replicon chromosome
Accession NZ_CP085525
Organism Sinorhizobium meliloti strain L6-AK89

Toxin (Protein)


Gene name hicA Uniprot ID H0G1A3
Locus tag LJD24_RS10460 Protein ID WP_003530010.1
Coordinates 2178005..2178193 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q92NX0
Locus tag LJD24_RS10465 Protein ID WP_010969659.1
Coordinates 2178198..2178659 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJD24_RS10445 (LJD24_10445) 2174571..2175881 + 1311 WP_010969656.1 HlyD family type I secretion periplasmic adaptor subunit -
LJD24_RS10450 (LJD24_10450) 2175906..2176877 - 972 WP_017265202.1 glycosyltransferase family 2 protein -
LJD24_RS10455 (LJD24_10455) 2177058..2177828 - 771 WP_010969658.1 Stf0 family sulphotransferase -
LJD24_RS10460 (LJD24_10460) 2178005..2178193 + 189 WP_003530010.1 type II toxin-antitoxin system HicA family toxin Toxin
LJD24_RS10465 (LJD24_10465) 2178198..2178659 + 462 WP_010969659.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LJD24_RS10475 (LJD24_10475) 2178978..2179895 - 918 WP_003530005.1 PhzF family phenazine biosynthesis protein -
LJD24_RS10480 (LJD24_10480) 2180072..2180821 - 750 WP_010969660.1 NUDIX hydrolase -
LJD24_RS10485 (LJD24_10485) 2180824..2181930 - 1107 WP_003530001.1 endonuclease -
LJD24_RS10490 (LJD24_10490) 2182081..2182524 - 444 WP_003529999.1 TIGR02594 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6971.15 Da        Isoelectric Point: 11.0889

>T220828 WP_003530010.1 NZ_CP085525:2178005-2178193 [Sinorhizobium meliloti]
MKSGDIIAALQKDGWYEVATKGSHVQFKHPKKHGRVTVPHPKRDLPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

>T220828 NZ_CP117298:71515-71916 [Mycobacterium tuberculosis variant bovis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16293.17 Da        Isoelectric Point: 4.3990

>AT220828 WP_010969659.1 NZ_CP085525:2178198-2178659 [Sinorhizobium meliloti]
MRNYIGLIHKDAESDYGVSFPDFSGVVTAGADLDDARAMAEEALALHIEGLVEDGEAIPEPSSLEVVMSDAENRDCVAIL
VAVKTEAKRAIRVNVTLPEGVLKQIDAFAEAHGLTRSGFLARAATHEIERANDGHDAYAESRLSALGTSSKNV

Download         Length: 462 bp

>AT220828 NZ_CP117298:71283-71522 [Mycobacterium tuberculosis variant bovis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGTAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G1A3

Antitoxin

Source ID Structure
AlphaFold DB Q92NX0

References