Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT_toxin-BrnA |
| Location | 637943..638520 | Replicon | chromosome |
| Accession | NZ_CP085525 | ||
| Organism | Sinorhizobium meliloti strain L6-AK89 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | - |
| Locus tag | LJD24_RS02970 | Protein ID | WP_014528972.1 |
| Coordinates | 637943..638206 (+) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | Q92KN5 |
| Locus tag | LJD24_RS02975 | Protein ID | WP_010968708.1 |
| Coordinates | 638203..638520 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJD24_RS02930 (LJD24_02930) | 633272..633712 | + | 441 | WP_014528946.1 | DUF2948 family protein | - |
| LJD24_RS02935 (LJD24_02935) | 633776..635080 | + | 1305 | WP_028004761.1 | histidinol dehydrogenase | - |
| LJD24_RS02940 (LJD24_02940) | 635077..635553 | + | 477 | WP_010968704.1 | UPF0262 family protein | - |
| LJD24_RS02945 (LJD24_02945) | 635567..636046 | + | 480 | WP_010968705.1 | low molecular weight phosphatase family protein | - |
| LJD24_RS02950 (LJD24_02950) | 636204..636422 | + | 219 | WP_004435948.1 | translation initiation factor IF-1 | - |
| LJD24_RS02955 (LJD24_02955) | 636521..637141 | + | 621 | WP_014528949.1 | Maf-like protein | - |
| LJD24_RS02960 (LJD24_02960) | 637146..637358 | + | 213 | WP_010968706.1 | DNA gyrase inhibitor YacG | - |
| LJD24_RS02970 (LJD24_02970) | 637943..638206 | + | 264 | WP_014528972.1 | BrnT family toxin | Toxin |
| LJD24_RS02975 (LJD24_02975) | 638203..638520 | + | 318 | WP_010968708.1 | BrnA antitoxin family protein | Antitoxin |
| LJD24_RS02980 (LJD24_02980) | 638723..639187 | - | 465 | WP_013844019.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LJD24_RS02985 (LJD24_02985) | 639184..639372 | - | 189 | WP_017266533.1 | hypothetical protein | - |
| LJD24_RS02990 (LJD24_02990) | 639691..640791 | + | 1101 | WP_017269979.1 | HPr kinase | - |
| LJD24_RS02995 (LJD24_02995) | 640778..641860 | + | 1083 | WP_014528975.1 | nucleotidyltransferase family protein | - |
| LJD24_RS03000 (LJD24_03000) | 642063..642374 | + | 312 | WP_014528976.1 | hypothetical protein | - |
| LJD24_RS03005 (LJD24_03005) | 642653..643042 | - | 390 | WP_013844021.1 | DUF930 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 9821.16 Da Isoelectric Point: 10.3413
>T220824 WP_014528972.1 NZ_CP085525:637943-638206 [Sinorhizobium meliloti]
MRIVWGEPKRRANLEKHGFDFADVSDLDWASAIIEDSKPDTSGRKRLKAIGYFRDGTAAVIFATLGTEAISIISFRPASD
RERRRLP
MRIVWGEPKRRANLEKHGFDFADVSDLDWASAIIEDSKPDTSGRKRLKAIGYFRDGTAAVIFATLGTEAISIISFRPASD
RERRRLP
Download Length: 264 bp
>T220824 NZ_CP117294:c4249316-4248825 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGTGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGTGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 12197.83 Da Isoelectric Point: 10.0883
>AT220824 WP_010968708.1 NZ_CP085525:638203-638520 [Sinorhizobium meliloti]
MTTRTRKSKTFEPGHGYTKEEWDAVDFPELTDEELTNMRPARDVLPPEFFKAMEEHRRSRGRPSLEHPKKQVTLRLDEDV
IAKFRAGGKGWQSRMNEALRKAAGI
MTTRTRKSKTFEPGHGYTKEEWDAVDFPELTDEELTNMRPARDVLPPEFFKAMEEHRRSRGRPSLEHPKKQVTLRLDEDV
IAKFRAGGKGWQSRMNEALRKAAGI
Download Length: 318 bp
>AT220824 NZ_CP117294:c4249606-4249313 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGTGAAACTCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGTTGGAAGCTGCCCGTGCTGCCGCAGAAGAAGTGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
ATGCCAGCCGCAAACAGTATGGCGATGAAACGTGAAACTCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGTTGGAAGCTGCCCGTGCTGCCGCAGAAGAAGTGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|