Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 914324..914891 Replicon chromosome
Accession NZ_CP085524
Organism Zhaonella formicivorans strain K32

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EYS13_RS04490 Protein ID WP_227766333.1
Coordinates 914324..914575 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EYS13_RS04495 Protein ID WP_227766335.1
Coordinates 914565..914891 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYS13_RS04480 912365..912793 + 429 WP_227766330.1 prepilin peptidase -
EYS13_RS04485 912839..913864 + 1026 WP_227766331.1 helix-turn-helix domain-containing protein -
EYS13_RS04490 914324..914575 + 252 WP_227766333.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
EYS13_RS04495 914565..914891 + 327 WP_227766335.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
EYS13_RS04500 914993..915568 + 576 WP_227766337.1 HD domain-containing protein -
EYS13_RS04505 915570..915839 + 270 WP_227766338.1 hypothetical protein -
EYS13_RS04510 915996..917273 + 1278 WP_227766341.1 hypothetical protein -
EYS13_RS04515 917428..917784 + 357 WP_227766342.1 hypothetical protein -
EYS13_RS04520 918071..918442 + 372 WP_227766344.1 hypothetical protein -
EYS13_RS04525 918456..919730 + 1275 WP_227766347.1 MobP3 family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 898085..949131 51046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(4-106)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9546.02 Da        Isoelectric Point: 4.4991

>T220821 WP_227766333.1 NZ_CP085524:914324-914575 [Zhaonella formicivorans]
MQIDVIRIGNSKGVRIPAALLKQCGIDKRVEVEVQENCIILKPVKIPREGWAAAFRRMNRNGDDVLLLPDELDNDLLEEW
DEY

Download         Length: 252 bp

>T220821 NZ_CP117294:c3907442-3907155 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12124.07 Da        Isoelectric Point: 7.6641

>AT220821 WP_227766335.1 NZ_CP085524:914565-914891 [Zhaonella formicivorans]
MNINQYDVYWTDLNPAKGSEINKVRPCVVISPPEMNAYLRTVIVAPVTSKGREGYPTRVYMSVSDVYGWVVLDQIRAIDK
SRLCNKIGSLDENAVCAIKSVIKEMLVD

Download         Length: 327 bp

>AT220821 NZ_CP117294:c3907168-3906866 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References