Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1223200..1224117 | Replicon | chromosome |
| Accession | NZ_CP085504 | ||
| Organism | Bacillus velezensis strain BP1.2A | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | HQN47_RS06475 | Protein ID | WP_012117368.1 |
| Coordinates | 1223371..1224117 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | I2HQ14 |
| Locus tag | HQN47_RS06470 | Protein ID | WP_003154807.1 |
| Coordinates | 1223200..1223370 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HQN47_RS06420 (HQN47_006420) | 1218334..1218846 | + | 513 | WP_012117362.1 | sigma-70 family RNA polymerase sigma factor | - |
| HQN47_RS06425 (HQN47_006425) | 1218959..1219192 | + | 234 | WP_012117363.1 | XtmA | - |
| HQN47_RS06430 (HQN47_006430) | 1219208..1220056 | + | 849 | WP_012117364.1 | hypothetical protein | - |
| HQN47_RS06435 (HQN47_006435) | 1220069..1220440 | + | 372 | WP_012117365.1 | XkdW family protein | - |
| HQN47_RS06440 (HQN47_006440) | 1220445..1220642 | + | 198 | WP_012117366.1 | XkdX family protein | - |
| HQN47_RS06445 (HQN47_006445) | 1220699..1221460 | + | 762 | WP_012117367.1 | hypothetical protein | - |
| HQN47_RS06450 (HQN47_006450) | 1221512..1221775 | + | 264 | WP_003154815.1 | hemolysin XhlA family protein | - |
| HQN47_RS06455 (HQN47_006455) | 1221789..1222052 | + | 264 | WP_003154813.1 | phage holin | - |
| HQN47_RS06460 (HQN47_006460) | 1222066..1222944 | + | 879 | WP_007407257.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HQN47_RS06465 (HQN47_006465) | 1222978..1223103 | - | 126 | WP_023356844.1 | hypothetical protein | - |
| HQN47_RS06470 (HQN47_006470) | 1223200..1223370 | - | 171 | WP_003154807.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
| HQN47_RS06475 (HQN47_006475) | 1223371..1224117 | - | 747 | WP_012117368.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| HQN47_RS06480 (HQN47_006480) | 1224222..1225220 | - | 999 | WP_007407255.1 | inorganic phosphate transporter | - |
| HQN47_RS06485 (HQN47_006485) | 1225233..1225850 | - | 618 | WP_003154804.1 | DUF47 domain-containing protein | - |
| HQN47_RS06490 (HQN47_006490) | 1226136..1227452 | - | 1317 | WP_007610842.1 | amino acid permease | - |
| HQN47_RS06495 (HQN47_006495) | 1227775..1228725 | + | 951 | WP_012117369.1 | ring-cleaving dioxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1210856..1281404 | 70548 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29119.61 Da Isoelectric Point: 4.7003
>T220813 WP_012117368.1 NZ_CP085504:c1224117-1223371 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAEWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQADKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAEWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQADKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
Download Length: 747 bp
>T220813 NZ_CP117293:c4677780-4677406 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG
Antitoxin
Download Length: 57 a.a. Molecular weight: 6676.74 Da Isoelectric Point: 10.9273
>AT220813 WP_003154807.1 NZ_CP085504:c1223370-1223200 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
Download Length: 171 bp
>AT220813 NZ_CP117293:c4678022-4677780 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|