Detailed information of TA system TA220809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2309455..2310433
• Replicon: chromosome
• Accession: NZ_CP085498
• Organism: Bacillus cereus strain A22

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: FHP23_RS11885
• Protein ID: WP_000624983.1
• Coordinates: 2309455..2310192 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W8YZL5
• Locus tag: FHP23_RS11890
• Protein ID: WP_000237818.1
• Coordinates: 2310305..2310433 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHP23_RS11860 (FHP23_011860)	2305071..2305478	+	408	WP_139848149.1	VOC family protein	-
FHP23_RS11865 (FHP23_011865)	2305491..2305880	+	390	Protein_2268	SAM-dependent methyltransferase	-
FHP23_RS11870 (FHP23_011870)	2306038..2307723	-	1686	WP_002196497.1	alpha-keto acid decarboxylase family protein	-
FHP23_RS11875 (FHP23_011875)	2307831..2308313	+	483	WP_000191888.1	MarR family winged helix-turn-helix transcriptional regulator	-
FHP23_RS11880 (FHP23_011880)	2308480..2309217	+	738	WP_000594152.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
FHP23_RS11885 (FHP23_011885)	2309455..2310192	+	738	WP_000624983.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
FHP23_RS11890 (FHP23_011890)	2310305..2310433	+	129	WP_000237818.1	hypothetical protein	Antitoxin
FHP23_RS11895 (FHP23_011895)	2310506..2310682	+	177	WP_000852629.1	stage II sporulation protein SB	-
FHP23_RS11900 (FHP23_011900)	2310702..2311091	-	390	WP_000713865.1	YxeA family protein	-
FHP23_RS11905 (FHP23_011905)	2311303..2312772	+	1470	WP_000287515.1	beta-Ala-His dipeptidase	-
FHP23_RS11910 (FHP23_011910)	2313018..2313827	+	810	WP_000678510.1	papain-like cysteine protease family protein	-
FHP23_RS11915 (FHP23_011915)	2313853..2314455	+	603	WP_000517260.1	hypothetical protein	-
FHP23_RS11920 (FHP23_011920)	2314696..2314947	-	252	WP_000827560.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28323.03 Da
• Isoelectric Point: 8.2998

>T220809 WP_000624983.1 NZ_CP085498:2309455-2310192 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDISF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T220809 NZ_CP117293:c3905808-3905521 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 5011.40 Da
• Isoelectric Point: 3.9150

>AT220809 WP_000237818.1 NZ_CP085498:2310305-2310433 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT220809 NZ_CP117293:c3905534-3905232 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Structures

Antitoxin

• AlphaFold DB: W8YZL5