Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 231982..232624 Replicon chromosome
Accession NZ_CP085498
Organism Bacillus cereus strain A22

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag FHP23_RS01290 Protein ID WP_000635965.1
Coordinates 232274..232624 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag FHP23_RS01285 Protein ID WP_000004570.1
Coordinates 231982..232269 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHP23_RS01260 (FHP23_001260) 227299..228261 + 963 WP_000961161.1 UV DNA damage repair endonuclease UvsE -
FHP23_RS01265 (FHP23_001265) 228254..228826 - 573 WP_000908524.1 rhomboid family intramembrane serine protease -
FHP23_RS01270 (FHP23_001270) 228920..229279 + 360 WP_000583417.1 holo-ACP synthase -
FHP23_RS01275 (FHP23_001275) 229436..230386 + 951 WP_002004297.1 outer membrane lipoprotein carrier protein LolA -
FHP23_RS01280 (FHP23_001280) 230504..231673 + 1170 WP_000390617.1 alanine racemase -
FHP23_RS01285 (FHP23_001285) 231982..232269 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
FHP23_RS01290 (FHP23_001290) 232274..232624 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FHP23_RS01295 (FHP23_001295) 232692..234860 + 2169 WP_000426236.1 Tex family protein -
FHP23_RS01300 (FHP23_001300) 234918..235034 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
FHP23_RS01305 (FHP23_001305) 235230..235688 + 459 WP_003311668.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T220808 WP_000635965.1 NZ_CP085498:232274-232624 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T220808 NZ_CP117293:c2776682-2776580 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT220808 WP_000004570.1 NZ_CP085498:231982-232269 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT220808 NZ_CP117293:2776578-2776721 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References