Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 873866..874431 | Replicon | chromosome |
| Accession | NC_009456 | ||
| Organism | Vibrio cholerae O395 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | VC0395_RS04125 | Protein ID | WP_000869999.1 |
| Coordinates | 873866..874153 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | VC0395_RS04130 | Protein ID | WP_000086649.1 |
| Coordinates | 874150..874431 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VC0395_RS04080 | 869122..869358 | - | 237 | WP_001065132.1 | hypothetical protein | - |
| VC0395_RS04085 | 869602..870027 | - | 426 | WP_000403003.1 | GNAT family N-acetyltransferase | - |
| VC0395_RS04090 | 870122..870532 | - | 411 | WP_000452031.1 | hypothetical protein | - |
| VC0395_RS04095 | 870647..871207 | - | 561 | Protein_796 | hypothetical protein | - |
| VC0395_RS04100 | 871207..871899 | - | 693 | WP_000780703.1 | hypothetical protein | - |
| VC0395_RS04105 | 872107..872289 | - | 183 | WP_001889223.1 | DUF645 family protein | - |
| VC0395_RS04115 | 872584..873033 | - | 450 | WP_000480555.1 | hypothetical protein | - |
| VC0395_RS04120 | 873168..873707 | - | 540 | WP_000884561.1 | hydrolase | - |
| VC0395_RS04125 | 873866..874153 | - | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VC0395_RS04130 | 874150..874431 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VC0395_RS04135 | 874645..875070 | - | 426 | WP_000735184.1 | hypothetical protein | - |
| VC0395_RS20570 | 875220..875306 | - | 87 | WP_071917830.1 | DUF3265 domain-containing protein | - |
| VC0395_RS04140 | 875306..875668 | - | 363 | WP_000454151.1 | hypothetical protein | - |
| VC0395_RS04145 | 875819..876277 | - | 459 | WP_000650937.1 | hypothetical protein | - |
| VC0395_RS04150 | 876486..876668 | - | 183 | WP_000947513.1 | DUF645 family protein | - |
| VC0395_RS04155 | 876971..877486 | - | 516 | WP_001201533.1 | lipocalin family protein | - |
| VC0395_RS19965 | 877513..877662 | - | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| VC0395_RS04160 | 877635..877886 | - | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| VC0395_RS04165 | 878081..878284 | - | 204 | WP_001911580.1 | hypothetical protein | - |
| VC0395_RS04170 | 878541..878927 | - | 387 | WP_000703163.1 | VOC family protein | - |
| VC0395_RS20760 | 878966..879076 | - | 111 | Protein_813 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 833458..916350 | 82892 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T22080 WP_000869999.1 NC_009456:c874153-873866 [Vibrio cholerae O395]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T22080 NC_009456:c874153-873866 [Vibrio cholerae O395]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT22080 WP_000086649.1 NC_009456:c874431-874150 [Vibrio cholerae O395]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT22080 NC_009456:c874431-874150 [Vibrio cholerae O395]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |