Detailed information of TA system TA220786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 106..580
• Replicon: plasmid p1_NMG38-2
• Accession: NZ_CP085483
• Organism: Proteus sp. NMG38-2

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: LG402_RS22175
• Protein ID: WP_125112842.1
• Coordinates: 314..580 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: LG402_RS22170
• Protein ID: WP_196712564.1
• Coordinates: 106..330 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG402_RS22170 (LG402_22165)	106..330	+	225	WP_196712564.1	DUF6290 family protein	Antitoxin
LG402_RS22175 (LG402_22170)	314..580	+	267	WP_125112842.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LG402_RS22180 (LG402_22175)	674..1558	-	885	WP_125112841.1	hypothetical protein	-
LG402_RS22185 (LG402_22180)	1555..2106	-	552	WP_125112840.1	hypothetical protein	-
LG402_RS22190 (LG402_22185)	3870..4568	+	699	WP_069368824.1	replication initiation protein	-
LG402_RS22195 (LG402_22190)	4571..4999	+	429	WP_177504730.1	DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..5500	5500

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (3-70)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10506.18 Da
• Isoelectric Point: 9.7513

>T220786 WP_125112842.1 NZ_CP085483:314-580 [Proteus sp. NMG38-2]
MVWTINYSERALKYLRKMDKQNARRIVDFMDLRIAALDDPRQSGKPLKGELGEFWRYRVGDYRILCEIRDNELIILATTI
GHRKSVYD

Nucleotide

• Length: 267 bp

>T220786 NZ_CP117291:c4009323-4009039 [Salmonella enterica subsp. enterica serovar Typhi]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8478.54 Da
• Isoelectric Point: 4.6652

>AT220786 WP_196712564.1 NZ_CP085483:106-330 [Proteus sp. NMG38-2]
MLAIRLSDDIETRLESLAKQTGRTKTFYAREAILTHLEDLEDYYLSAEIVAKIRRGEEQVHSAEDVRKALGLDD

Nucleotide

• Length: 225 bp

>AT220786 NZ_CP117291:c4009555-4009313 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA