Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 803468..804080 Replicon chromosome
Accession NZ_CP085481
Organism Proteus sp. NMG38-2

Toxin (Protein)


Gene name Hha Uniprot ID A0A379EIK6
Locus tag LG402_RS03765 Protein ID WP_006535062.1
Coordinates 803468..803671 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LG402_RS03770 Protein ID WP_109407971.1
Coordinates 803718..804080 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG402_RS03745 (LG402_03745) 800130..800468 + 339 WP_227336448.1 P-II family nitrogen regulator -
LG402_RS03750 (LG402_03750) 800481..801773 + 1293 WP_227336449.1 ammonium transporter AmtB -
LG402_RS03755 (LG402_03755) 801817..802692 - 876 WP_109407972.1 acyl-CoA thioesterase II -
LG402_RS03765 (LG402_03765) 803468..803671 - 204 WP_006535062.1 HHA domain-containing protein Toxin
LG402_RS03770 (LG402_03770) 803718..804080 - 363 WP_109407971.1 Hha toxicity modulator TomB Antitoxin
LG402_RS03775 (LG402_03775) 804711..807860 - 3150 WP_166539499.1 efflux RND transporter permease subunit -
LG402_RS03780 (LG402_03780) 807875..809068 - 1194 WP_109407969.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T220784 WP_006535062.1 NZ_CP085481:c803671-803468 [Proteus sp. NMG38-2]
MTKTDYLMRLRKCTSIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T220784 NZ_CP117291:c2777400-2777298 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.89 Da        Isoelectric Point: 4.6034

>AT220784 WP_109407971.1 NZ_CP085481:c804080-803718 [Proteus sp. NMG38-2]
MDEYSPEKVDLAELSFLCEELLQQALGSLDKGNTVWHNDLSSTKSVDLNVLIEHIMDFSWKFKIKYPDKQVINTLIEEYL
EETYRLFGNTSISYSDINNWKELNHSLLTLIAKNPKSYIK

Download         Length: 363 bp

>AT220784 NZ_CP117291:2777296-2777439 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379EIK6

Antitoxin

Source ID Structure

References