Detailed information of TA system TA220783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 755479..756118
• Replicon: chromosome
• Accession: NZ_CP085481
• Organism: Proteus sp. NMG38-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LG402_RS03545
• Protein ID: WP_166539476.1
• Coordinates: 755479..755883 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LG402_RS03550
• Protein ID: WP_088493701.1
• Coordinates: 755876..756118 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG402_RS03515 (LG402_03515)	750720..751169	+	450	WP_006535128.1	transcriptional regulator NrdR	-
LG402_RS03520 (LG402_03520)	751240..752394	+	1155	WP_227336439.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
LG402_RS03525 (LG402_03525)	752607..753077	+	471	WP_036932916.1	6,7-dimethyl-8-ribityllumazine synthase	-
LG402_RS03530 (LG402_03530)	753106..753522	+	417	WP_109408009.1	transcription antitermination factor NusB	-
LG402_RS03535 (LG402_03535)	753626..754609	+	984	WP_109408008.1	thiamine-phosphate kinase	-
LG402_RS03540 (LG402_03540)	754704..755039	-	336	WP_166539475.1	zinc ribbon domain-containing protein YjdM	-
LG402_RS03545 (LG402_03545)	755479..755883	-	405	WP_166539476.1	type II toxin-antitoxin system VapC family toxin	Toxin
LG402_RS03550 (LG402_03550)	755876..756118	-	243	WP_088493701.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LG402_RS03555 (LG402_03555)	756237..757244	-	1008	WP_227336440.1	ribose operon transcriptional repressor RbsR	-
LG402_RS03560 (LG402_03560)	757249..758175	-	927	WP_166539477.1	ribokinase	-
LG402_RS03565 (LG402_03565)	758251..759141	-	891	WP_166539478.1	ribose ABC transporter substrate-binding protein RbsB	-
LG402_RS03570 (LG402_03570)	759184..760149	-	966	WP_166539479.1	ribose ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15313.52 Da
• Isoelectric Point: 7.4647

>T220783 WP_166539476.1 NZ_CP085481:c755883-755479 [Proteus sp. NMG38-2]
MIKYLLDTNIVIFTIKRRPEFLLPKFNQYVEQLAISTITLAELLYGAEKSSNSAKNLATVNDFVSRLNVLPYDELAAFHY
GDIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTKEFERVDGLRIEDWTHH

Nucleotide

• Length: 405 bp

>T220783 NZ_CP117291:c1390773-1390555 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9316.41 Da
• Isoelectric Point: 4.7969

>AT220783 WP_088493701.1 NZ_CP085481:c756118-755876 [Proteus sp. NMG38-2]
MIQHGKVFMSNRTQNVRLPADTRFPDDVKDVVVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQVTSERESFDD

Nucleotide

• Length: 243 bp

>AT220783 NZ_CP117291:c1391175-1390801 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA