220758

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4623278..4624335 Replicon chromosome
Accession NZ_CP085465
Organism Aeromonas veronii strain 71506

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LEO77_RS20995 Protein ID WP_227341695.1
Coordinates 4623278..4624081 (-) Length 268 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LEO77_RS21000 Protein ID WP_017410478.1
Coordinates 4624081..4624335 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEO77_RS20970 (LEO77_20970) 4618375..4618617 + 243 Protein_4041 IS3 family transposase -
LEO77_RS20975 (LEO77_20975) 4618807..4620681 + 1875 WP_227341692.1 HAD-IB family phosphatase -
LEO77_RS20980 (LEO77_20980) 4620722..4621996 + 1275 WP_227341693.1 hypothetical protein -
LEO77_RS20985 (LEO77_20985) 4622013..4622993 + 981 WP_216952506.1 hypothetical protein -
LEO77_RS20990 (LEO77_20990) 4622946..4623137 - 192 WP_227341694.1 hypothetical protein -
LEO77_RS20995 (LEO77_20995) 4623278..4624081 - 804 WP_227341695.1 HipA N-terminal domain-containing protein Toxin
LEO77_RS21000 (LEO77_21000) 4624081..4624335 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
LEO77_RS21005 (LEO77_21005) 4625031..4626044 - 1014 WP_000845039.1 class 1 integron integrase IntI1 -
LEO77_RS21010 (LEO77_21010) 4626189..4626686 + 498 WP_001083725.1 trimethoprim-resistant dihydrofolate reductase DfrA12 -
LEO77_RS21015 (LEO77_21015) 4626798..4627088 + 291 WP_001336345.1 DUF1010 domain-containing protein -
LEO77_RS21020 (LEO77_21020) 4627094..4627932 + 839 Protein_4051 AadA family aminoglycoside 3''-O-nucleotidyltransferase -
LEO77_RS21025 (LEO77_21025) 4628049..4628396 + 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
LEO77_RS21030 (LEO77_21030) 4628390..4629229 + 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island dfrA12 / aadA2 / qacE / sul1 / mph(A) / aph(3')-Ia - 4618807..4652391 33584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 268 a.a.        Molecular weight: 30339.39 Da        Isoelectric Point: 6.2959

>T220758 WP_227341695.1 NZ_CP085465:c4624081-4623278 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHHFQYHESWLAQPGSRPISLSMPLRHQTYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQASNVVKNQQ

Download         Length: 804 bp

>T220758 NZ_CP117287:c296277-296023 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTTTAATTTTACTGAAGAGGCTTGGGAAGATTACACTTCTTGGCAAAGAGAAGATAAAAAAAATCTCAAGCGTATTAA
TCGACTGATTGAAGATATCAAACGTCACCCTTTCGAAGGAATCGGAAAACCAGAACCTTTAAAATATCGGTATTCTGGTG
CCTGGTCTCGCCGTATTACAGACGAACACCGTCTCGTTTATACGGTAGAACAAAATGATATCTATTTCTTATCTTTTAGA
GATCACTATAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT220758 WP_017410478.1 NZ_CP085465:c4624335-4624081 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp

>AT220758 NZ_CP117287:c296536-296270 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGAAGCTGTTGTTTATTCAAATTTTAGAAACAATTTAAAAGATTACATGAAAAAGGTAAATGATGAATACGAGCCATT
AATGGTAGTTAATAAAAACCCTGAAGAAAATATCGTGGTCTTGTCTAAAGACAATTGGGATAGTATTCAAGAAACCATTC
GTATCATGAATAACGAATACCTCTCTGATAAAGTTCTATCAGGATTGGAACAAGTCAAACAAAAGAAAGTGACCCAACAC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References