Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazF-pemI/MazF(toxin) |
Location | 200786..201422 | Replicon | chromosome |
Accession | NZ_CP085426 | ||
Organism | Priestia megaterium strain F16 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | D5DWT4 |
Locus tag | LIT30_RS01135 | Protein ID | WP_013055004.1 |
Coordinates | 201072..201422 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | D5DWT3 |
Locus tag | LIT30_RS01130 | Protein ID | WP_013055003.1 |
Coordinates | 200786..201067 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LIT30_RS01105 (LIT30_01105) | 196152..197123 | + | 972 | WP_252298683.1 | UV DNA damage repair endonuclease UvsE | - |
LIT30_RS01110 (LIT30_01110) | 197132..197734 | - | 603 | WP_013054999.1 | rhomboid family intramembrane serine protease | - |
LIT30_RS01115 (LIT30_01115) | 197799..198164 | + | 366 | WP_013055000.1 | holo-ACP synthase | - |
LIT30_RS01120 (LIT30_01120) | 198223..199281 | + | 1059 | WP_013055001.1 | outer membrane lipoprotein carrier protein LolA | - |
LIT30_RS01125 (LIT30_01125) | 199395..200585 | + | 1191 | WP_013055002.1 | alanine racemase | - |
LIT30_RS01130 (LIT30_01130) | 200786..201067 | + | 282 | WP_013055003.1 | hypothetical protein | Antitoxin |
LIT30_RS01135 (LIT30_01135) | 201072..201422 | + | 351 | WP_013055004.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
LIT30_RS01140 (LIT30_01140) | 201580..202416 | + | 837 | WP_013055005.1 | RsbT co-antagonist protein RsbRA | - |
LIT30_RS01145 (LIT30_01145) | 202419..202775 | + | 357 | WP_013055006.1 | STAS domain-containing protein | - |
LIT30_RS01150 (LIT30_01150) | 202779..203180 | + | 402 | WP_013055007.1 | anti-sigma regulatory factor | - |
LIT30_RS01155 (LIT30_01155) | 203194..204204 | + | 1011 | WP_013055008.1 | PP2C family protein-serine/threonine phosphatase | - |
LIT30_RS01160 (LIT30_01160) | 204264..204596 | + | 333 | WP_013055009.1 | anti-sigma factor antagonist | - |
LIT30_RS01165 (LIT30_01165) | 204593..205078 | + | 486 | WP_013055010.1 | anti-sigma B factor RsbW | - |
LIT30_RS01170 (LIT30_01170) | 205044..205838 | + | 795 | WP_013055011.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12991.96 Da Isoelectric Point: 4.8781
>T220755 WP_013055004.1 NZ_CP085426:201072-201422 [Priestia megaterium]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF
Download Length: 351 bp
>T220755 NZ_CP117285:c294951-294697 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTTTAATTTTACTGAAGAGGCTTGGGAAGATTACACTTCTTGGCAAAGAGAAGATAAAAAAAATCTCAAGCGTATTAA
TCGACTGATTGAAGATATCAAACGTCACCCTTTCGAAGGAATCGGAAAACCAGAACCTTTAAAATATCGGTATTCTGGTG
CCTGGTCTCGCCGTATTACAGACGAACACCGTCTCGTTTATACGGTAGAACAAAATGATATCTATTTCTTATCTTTTAGA
GATCACTATAAGTAA
ATGTTTAATTTTACTGAAGAGGCTTGGGAAGATTACACTTCTTGGCAAAGAGAAGATAAAAAAAATCTCAAGCGTATTAA
TCGACTGATTGAAGATATCAAACGTCACCCTTTCGAAGGAATCGGAAAACCAGAACCTTTAAAATATCGGTATTCTGGTG
CCTGGTCTCGCCGTATTACAGACGAACACCGTCTCGTTTATACGGTAGAACAAAATGATATCTATTTCTTATCTTTTAGA
GATCACTATAAGTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10691.22 Da Isoelectric Point: 8.5339
>AT220755 WP_013055003.1 NZ_CP085426:200786-201067 [Priestia megaterium]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG
Download Length: 282 bp
>AT220755 NZ_CP117285:c295210-294944 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGAAGCTGTTGTTTATTCAAATTTTAGAAACAATTTAAAAGATTACATGAAAAAGGTAAATGATGAATACGAGCCATT
AATGGTAGTTAATAAAAACCCTGAAGAAAATATCGTGGTCTTGTCTAAAGACAATTGGGATAGTATTCAAGAAACCATTC
GTATCATGAATAACGAATACCTCTCTGATAAAGTTCTATCAGGATTGGAACAAGTCAAACAAAAGAAAGTGACCCAACAC
CAATTATTAGAGGTGGAAGATGTTTAA
ATGGAAGCTGTTGTTTATTCAAATTTTAGAAACAATTTAAAAGATTACATGAAAAAGGTAAATGATGAATACGAGCCATT
AATGGTAGTTAATAAAAACCCTGAAGAAAATATCGTGGTCTTGTCTAAAGACAATTGGGATAGTATTCAAGAAACCATTC
GTATCATGAATAACGAATACCTCTCTGATAAAGTTCTATCAGGATTGGAACAAGTCAAACAAAAGAAAGTGACCCAACAC
CAATTATTAGAGGTGGAAGATGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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