Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2408753..2409728 Replicon chromosome
Accession NZ_CP085413
Organism Bacillus paranthracis strain KF11

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag LIS80_RS12360 Protein ID WP_002027714.1
Coordinates 2408753..2409490 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag LIS80_RS12365 Protein ID WP_000588712.1
Coordinates 2409603..2409728 (+) Length 42 a.a.

Genomic Context

LIS80_RS12330LIS80_RS12335LIS80_RS12340LIS80_RS12350LIS80_RS12355LIS80_RS12360LIS80_RS12365LIS80_RS12370LIS80_RS12375LIS80_RS12385LIS80_RS12390LIS80_RS12395LIS80_RS12345LIS80_RS12380
Location: 2403828..2404538 (711 bp)
Type: Others
Protein ID: WP_000787475.1
Location: 2404658..2405065 (408 bp)
Type: Others
Protein ID: WP_000072484.1
Location: 2405171..2405263 (93 bp)
Type: Others
Protein ID: Protein_2359
Location: 2407177..2407659 (483 bp)
Type: Others
Protein ID: WP_000191904.1
Location: 2407827..2408564 (738 bp)
Type: Others
Protein ID: WP_000594123.1
Location: 2408753..2409490 (738 bp)
Type: Toxin
Protein ID: WP_002027714.1
Location: 2409603..2409728 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 2409804..2409980 (177 bp)
Type: Others
Protein ID: WP_000852623.1
Location: 2410124..2411593 (1470 bp)
Type: Others
Protein ID: WP_000287524.1
Location: 2412184..2412777 (594 bp)
Type: Others
Protein ID: WP_000265892.1
Location: 2412999..2413532 (534 bp)
Type: Others
Protein ID: WP_000438320.1
Location: 2413522..2414349 (828 bp)
Type: Others
Protein ID: WP_001060777.1
Location: 2405385..2407070 (1686 bp)
Type: Others
Protein ID: WP_002027713.1
Location: 2411670..2412041 (372 bp)
Type: Others
Protein ID: WP_000670601.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LIS80_RS12330 (LIS80_12335)2403828..2404538+711WP_000787475.1class I SAM-dependent methyltransferase-
LIS80_RS12335 (LIS80_12340)2404658..2405065+408WP_000072484.1VOC family protein-
LIS80_RS12340 (LIS80_12345)2405171..2405263+93Protein_2359methyltransferase-
LIS80_RS12345 (LIS80_12350)2405385..2407070-1686WP_002027713.1alpha-keto acid decarboxylase family protein-
LIS80_RS12350 (LIS80_12355)2407177..2407659+483WP_000191904.1MarR family transcriptional regulator-
LIS80_RS12355 (LIS80_12360)2407827..2408564+738WP_000594123.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
LIS80_RS12360 (LIS80_12365)2408753..2409490+738WP_002027714.1type II toxin-antitoxin system SpoIISA family toxinToxin
LIS80_RS12365 (LIS80_12370)2409603..2409728+126WP_000588712.1hypothetical proteinAntitoxin
LIS80_RS12370 (LIS80_12375)2409804..2409980+177WP_000852623.1stage II sporulation protein SB-
LIS80_RS12375 (LIS80_12380)2410124..2411593+1470WP_000287524.1beta-Ala-His dipeptidase-
LIS80_RS12380 (LIS80_12385)2411670..2412041-372WP_000670601.1DUF5065 family protein-
LIS80_RS12385 (LIS80_12390)2412184..2412777+594WP_000265892.1SGNH/GDSL hydrolase family protein-
LIS80_RS12390 (LIS80_12395)2412999..2413532+534WP_000438320.1sigma-70 family RNA polymerase sigma factor-
LIS80_RS12395 (LIS80_12400)2413522..2414349+828WP_001060777.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T220753 WP_002027714.1 NZ_CP085413:2408753-2409490 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T220753 NZ_CP117284:c884842-883997 [Streptococcus dysgalactiae subsp. equisimilis]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTGATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAACTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATAACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTCCAAACCATCTATTCACGAAACTTCTTGAACAGCAGAAG
CAAAGACTTTTACGATGTTTATATTCTTTCAAAATTGAAGAAAAAAGATATTGATTTCAATCAGTTAAAAAATGCTTGCC
AAAGAACTTTTTCCTATCGCGAAACTGAGCTCGATTTCGAAAAAATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAATTATTCAAAAAAATATAGTTATACAAAAGGAATTTCACTTGCAAATGTGCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACTGACTCTGATTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT220753 WP_000588712.1 NZ_CP085413:2409603-2409728 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT220753 NZ_CP117284:c885429-884839 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGCATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAACATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTATGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5M9H7T3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References