Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2408753..2409728 Replicon chromosome
Accession NZ_CP085413
Organism Bacillus paranthracis strain KF11

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag LIS80_RS12360 Protein ID WP_002027714.1
Coordinates 2408753..2409490 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag LIS80_RS12365 Protein ID WP_000588712.1
Coordinates 2409603..2409728 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS80_RS12330 (LIS80_12335) 2403828..2404538 + 711 WP_000787475.1 class I SAM-dependent methyltransferase -
LIS80_RS12335 (LIS80_12340) 2404658..2405065 + 408 WP_000072484.1 VOC family protein -
LIS80_RS12340 (LIS80_12345) 2405171..2405263 + 93 Protein_2359 methyltransferase -
LIS80_RS12345 (LIS80_12350) 2405385..2407070 - 1686 WP_002027713.1 alpha-keto acid decarboxylase family protein -
LIS80_RS12350 (LIS80_12355) 2407177..2407659 + 483 WP_000191904.1 MarR family transcriptional regulator -
LIS80_RS12355 (LIS80_12360) 2407827..2408564 + 738 WP_000594123.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
LIS80_RS12360 (LIS80_12365) 2408753..2409490 + 738 WP_002027714.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
LIS80_RS12365 (LIS80_12370) 2409603..2409728 + 126 WP_000588712.1 hypothetical protein Antitoxin
LIS80_RS12370 (LIS80_12375) 2409804..2409980 + 177 WP_000852623.1 stage II sporulation protein SB -
LIS80_RS12375 (LIS80_12380) 2410124..2411593 + 1470 WP_000287524.1 beta-Ala-His dipeptidase -
LIS80_RS12380 (LIS80_12385) 2411670..2412041 - 372 WP_000670601.1 DUF5065 family protein -
LIS80_RS12385 (LIS80_12390) 2412184..2412777 + 594 WP_000265892.1 SGNH/GDSL hydrolase family protein -
LIS80_RS12390 (LIS80_12395) 2412999..2413532 + 534 WP_000438320.1 sigma-70 family RNA polymerase sigma factor -
LIS80_RS12395 (LIS80_12400) 2413522..2414349 + 828 WP_001060777.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T220753 WP_002027714.1 NZ_CP085413:2408753-2409490 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T220753 NZ_CP117284:c884842-883997 [Streptococcus dysgalactiae subsp. equisimilis]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTGATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAACTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATAACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTCCAAACCATCTATTCACGAAACTTCTTGAACAGCAGAAG
CAAAGACTTTTACGATGTTTATATTCTTTCAAAATTGAAGAAAAAAGATATTGATTTCAATCAGTTAAAAAATGCTTGCC
AAAGAACTTTTTCCTATCGCGAAACTGAGCTCGATTTCGAAAAAATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAATTATTCAAAAAAATATAGTTATACAAAAGGAATTTCACTTGCAAATGTGCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACTGACTCTGATTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT220753 WP_000588712.1 NZ_CP085413:2409603-2409728 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT220753 NZ_CP117284:c885429-884839 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATGGCATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAACATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTATGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M9H7T3

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References