Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 252385..253027 Replicon chromosome
Accession NZ_CP085413
Organism Bacillus paranthracis strain KF11

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag LIS80_RS01415 Protein ID WP_000635963.1
Coordinates 252677..253027 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag LIS80_RS01410 Protein ID WP_000004570.1
Coordinates 252385..252672 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS80_RS01385 (LIS80_01385) 247711..248673 + 963 WP_000961150.1 UV DNA damage repair endonuclease UvsE -
LIS80_RS01390 (LIS80_01390) 248666..249238 - 573 WP_001993582.1 rhomboid family intramembrane serine protease -
LIS80_RS01395 (LIS80_01395) 249331..249690 + 360 WP_000635037.1 holo-ACP synthase -
LIS80_RS01400 (LIS80_01400) 249847..250797 + 951 WP_025991724.1 outer membrane lipoprotein carrier protein LolA -
LIS80_RS01405 (LIS80_01405) 250916..252085 + 1170 WP_000390601.1 alanine racemase -
LIS80_RS01410 (LIS80_01410) 252385..252672 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
LIS80_RS01415 (LIS80_01415) 252677..253027 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
LIS80_RS01420 (LIS80_01420) 253095..255263 + 2169 WP_000450602.1 Tex family protein -
LIS80_RS01425 (LIS80_01425) 255321..255437 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
LIS80_RS01430 (LIS80_01430) 255633..256091 + 459 WP_000344246.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T220752 WP_000635963.1 NZ_CP085413:252677-253027 [Bacillus paranthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T220752 NZ_CP117284:c294951-294697 [Streptococcus dysgalactiae subsp. equisimilis]
ATGTTTAATTTTACTGAAGAGGCTTGGGAAGATTACACTTCTTGGCAAAGAGAAGATAAAAAAAATCTCAAGCGTATTAA
TCGACTGATTGAAGATATCAAACGTCACCCTTTCGAAGGAATCGGAAAACCAGAACCTTTAAAATATCGGTATTCTGGTG
CCTGGTCTCGCCGTATTACAGACGAACACCGTCTCGTTTATACGGTAGAACAAAATGATATCTATTTCTTATCTTTTAGA
GATCACTATAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT220752 WP_000004570.1 NZ_CP085413:252385-252672 [Bacillus paranthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT220752 NZ_CP117284:c295210-294944 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGAAGCTGTTGTTTATTCAAATTTTAGAAACAATTTAAAAGATTACATGAAAAAGGTAAATGATGAATACGAGCCATT
AATGGTAGTTAATAAAAACCCTGAAGAAAATATCGTGGTCTTGTCTAAAGACAATTGGGATAGTATTCAAGAAACCATTC
GTATCATGAATAACGAATACCTCTCTGATAAAGTTCTATCAGGATTGGAACAAGTCAAACAAAAGAAAGTGACCCAACAC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References