Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2311166..2312144 | Replicon | chromosome |
| Accession | NZ_CP085406 | ||
| Organism | Bacillus bombysepticus strain F12 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | W8Y388 |
| Locus tag | LIT24_RS11945 | Protein ID | WP_000624977.1 |
| Coordinates | 2311166..2311903 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | W8YZL5 |
| Locus tag | LIT24_RS11950 | Protein ID | WP_000237818.1 |
| Coordinates | 2312016..2312144 (+) | Length | 43 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LIT24_RS11920 (LIT24_11920) | 2306782..2307189 | + | 408 | WP_000072493.1 | VOC family protein | - |
| LIT24_RS11925 (LIT24_11925) | 2307202..2307591 | + | 390 | Protein_2271 | SAM-dependent methyltransferase | - |
| LIT24_RS11930 (LIT24_11930) | 2307749..2309434 | - | 1686 | WP_033689678.1 | alpha-keto acid decarboxylase family protein | - |
| LIT24_RS11935 (LIT24_11935) | 2309542..2310024 | + | 483 | WP_000191888.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| LIT24_RS11940 (LIT24_11940) | 2310191..2310928 | + | 738 | WP_000594150.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| LIT24_RS11945 (LIT24_11945) | 2311166..2311903 | + | 738 | WP_000624977.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| LIT24_RS11950 (LIT24_11950) | 2312016..2312144 | + | 129 | WP_000237818.1 | hypothetical protein | Antitoxin |
| LIT24_RS11955 (LIT24_11955) | 2312217..2312393 | + | 177 | WP_000852629.1 | stage II sporulation protein SB | - |
| LIT24_RS11960 (LIT24_11960) | 2312412..2312801 | - | 390 | WP_000713866.1 | YxeA family protein | - |
| LIT24_RS11965 (LIT24_11965) | 2313013..2314482 | + | 1470 | WP_000287515.1 | beta-Ala-His dipeptidase | - |
| LIT24_RS11970 (LIT24_11970) | 2314728..2315537 | + | 810 | WP_044584465.1 | papain-like cysteine protease family protein | - |
| LIT24_RS11975 (LIT24_11975) | 2315563..2316165 | + | 603 | WP_000517260.1 | hypothetical protein | - |
| LIT24_RS11980 (LIT24_11980) | 2316406..2316657 | - | 252 | WP_030025648.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28307.03 Da Isoelectric Point: 8.2998
>T220749 WP_000624977.1 NZ_CP085406:2311166-2311903 [Bacillus bombysepticus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T220749 NZ_CP117268:1157549-1157971 [Rhizobium rhododendri]
ATGAGACTGCTCCTCGACACCAATGTTCTGTCCGAAGTTACAAAACCTCGCCCGGCTGAATGTGTCTTGAATTGGCTTCA
CGGGCTTGACGAGGATCGCACATTCATCAGCATAGTCTCGATTGCCGAAATCCGCCGCGGCGTTGCGCTGATGGACATTG
GGCGAAAGCGCGACGCCTTGGACACGTGGCTTACGCATGATCTGCCACAACGTTTTGACAACAGGATTATTCCGGTCGAA
GCGCATCTTGCCTTGGCTTGGGGTGACCTCATGGCTCTCGCCAAGCGAAGCGGGCGGGGACTGGCATCCATGGACGGTCT
GATCGCTGCCACCGCCGTCGCTCGCGATTTGACGCTTGCGACACGCAATACAAAGGATTTCGAAGGCTTCGGAATAGACC
TCGTTGACCCATGGGAGGTCTGA
ATGAGACTGCTCCTCGACACCAATGTTCTGTCCGAAGTTACAAAACCTCGCCCGGCTGAATGTGTCTTGAATTGGCTTCA
CGGGCTTGACGAGGATCGCACATTCATCAGCATAGTCTCGATTGCCGAAATCCGCCGCGGCGTTGCGCTGATGGACATTG
GGCGAAAGCGCGACGCCTTGGACACGTGGCTTACGCATGATCTGCCACAACGTTTTGACAACAGGATTATTCCGGTCGAA
GCGCATCTTGCCTTGGCTTGGGGTGACCTCATGGCTCTCGCCAAGCGAAGCGGGCGGGGACTGGCATCCATGGACGGTCT
GATCGCTGCCACCGCCGTCGCTCGCGATTTGACGCTTGCGACACGCAATACAAAGGATTTCGAAGGCTTCGGAATAGACC
TCGTTGACCCATGGGAGGTCTGA
Antitoxin
Download Length: 43 a.a. Molecular weight: 5011.40 Da Isoelectric Point: 3.9150
>AT220749 WP_000237818.1 NZ_CP085406:2312016-2312144 [Bacillus bombysepticus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS
Download Length: 129 bp
>AT220749 NZ_CP117268:1157286-1157552 [Rhizobium rhododendri]
ATGCGCGCATCAACGCACAATGATATGAGCTGGACGGTTGCGGGAGCAAAGGCGAGACTCTCGGAGGTGATGGAGCGCGC
GCAGGCAGCGCCTCAGACCATTACCCGCAACGGGAAGCCGAGCGTGGTGGTCGTCTCTGCCGAGGAGTGGGAGAAGAAGA
CCGCGCGTAGGGGATCGCTTGCGGAATTTCTATTGGCATCGCCTCTGCGTGGCGCCGATATGGACATTGAGCGACTAAGC
GACGAGCCGCGCGACTTGTCCCTATGA
ATGCGCGCATCAACGCACAATGATATGAGCTGGACGGTTGCGGGAGCAAAGGCGAGACTCTCGGAGGTGATGGAGCGCGC
GCAGGCAGCGCCTCAGACCATTACCCGCAACGGGAAGCCGAGCGTGGTGGTCGTCTCTGCCGAGGAGTGGGAGAAGAAGA
CCGCGCGTAGGGGATCGCTTGCGGAATTTCTATTGGCATCGCCTCTGCGTGGCGCCGATATGGACATTGAGCGACTAAGC
GACGAGCCGCGCGACTTGTCCCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|