Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2457494..2458469 | Replicon | chromosome |
| Accession | NZ_CP085402 | ||
| Organism | Bacillus anthracis strain CMF9 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | LIS83_RS12525 | Protein ID | WP_052494343.1 |
| Coordinates | 2457494..2458231 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | C2VTW9 |
| Locus tag | LIS83_RS12530 | Protein ID | WP_000588936.1 |
| Coordinates | 2458344..2458469 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LIS83_RS12500 (LIS83_12515) | 2453001..2453702 | + | 702 | WP_001294994.1 | hypothetical protein | - |
| LIS83_RS12505 (LIS83_12520) | 2453825..2454709 | + | 885 | WP_042512702.1 | hypothetical protein | - |
| LIS83_RS12510 (LIS83_12525) | 2455029..2455811 | - | 783 | Protein_2387 | thiamine pyrophosphate-binding protein | - |
| LIS83_RS12515 (LIS83_12530) | 2455918..2456400 | + | 483 | WP_042512701.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| LIS83_RS12520 (LIS83_12535) | 2456568..2457305 | + | 738 | WP_042512700.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| LIS83_RS12525 (LIS83_12540) | 2457494..2458231 | + | 738 | WP_052494343.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| LIS83_RS12530 (LIS83_12545) | 2458344..2458469 | + | 126 | WP_000588936.1 | hypothetical protein | Antitoxin |
| LIS83_RS12535 (LIS83_12550) | 2458492..2458722 | + | 231 | WP_272884633.1 | stage II sporulation protein SB | - |
| LIS83_RS12540 (LIS83_12555) | 2458759..2459040 | - | 282 | WP_001041554.1 | hypothetical protein | - |
| LIS83_RS29525 | 2459273..2459398 | + | 126 | WP_000694311.1 | hypothetical protein | - |
| LIS83_RS12545 (LIS83_12560) | 2459475..2459651 | + | 177 | WP_042512697.1 | stage II sporulation protein SB | - |
| LIS83_RS12550 (LIS83_12565) | 2459795..2461264 | + | 1470 | WP_042512696.1 | beta-Ala-His dipeptidase | - |
| LIS83_RS12555 (LIS83_12570) | 2461846..2462316 | - | 471 | WP_000670597.1 | DUF5065 family protein | - |
| LIS83_RS12560 (LIS83_12575) | 2462493..2463113 | + | 621 | WP_127813147.1 | SGNH/GDSL hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28358.10 Da Isoelectric Point: 8.9957
>T220747 WP_052494343.1 NZ_CP085402:2457494-2458231 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T220747 NZ_CP117268:467783-468211 [Rhizobium rhododendri]
ATGATCCTGCTCGATACCAACGTTATTTCCGAGCCGCTCAAGTCGCAACCCGATCCACGGGTGGCCGCATGGATCGATAC
GCAGGCCGTCGAAACCCTCTACGTCGCTGCGATCTCACTCGCGGAATTGCGCTACGGCATCGCCGTGCATCCTGACGGCA
AGAAGAAACAAGCCGCGCAGGAAAAGCTTGATCGGTTGATGCTGCCTTTGTTCCGGGGCCGCATCATGCCGTTCGATGAA
GCCGCCGCCCAGGCTTATGCCGAGCTGCGGGCCGCAGCGGCGAAGAAGGGCAAGGCGATCGGCGATTCAGACGGCTATAT
CGCTGCCACGGCCAAGGCGAATGGTCTGATGATCGCCACCCGCGACACCAGCCCTTTCGAGGCCGCCGGCCTGACTGTCA
TCAATCCGTGGGAGGCATCTAATGGCTGA
ATGATCCTGCTCGATACCAACGTTATTTCCGAGCCGCTCAAGTCGCAACCCGATCCACGGGTGGCCGCATGGATCGATAC
GCAGGCCGTCGAAACCCTCTACGTCGCTGCGATCTCACTCGCGGAATTGCGCTACGGCATCGCCGTGCATCCTGACGGCA
AGAAGAAACAAGCCGCGCAGGAAAAGCTTGATCGGTTGATGCTGCCTTTGTTCCGGGGCCGCATCATGCCGTTCGATGAA
GCCGCCGCCCAGGCTTATGCCGAGCTGCGGGCCGCAGCGGCGAAGAAGGGCAAGGCGATCGGCGATTCAGACGGCTATAT
CGCTGCCACGGCCAAGGCGAATGGTCTGATGATCGCCACCCGCGACACCAGCCCTTTCGAGGCCGCCGGCCTGACTGTCA
TCAATCCGTGGGAGGCATCTAATGGCTGA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4888.29 Da Isoelectric Point: 3.9798
>AT220747 WP_000588936.1 NZ_CP085402:2458344-2458469 [Bacillus anthracis]
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
Download Length: 126 bp
>AT220747 NZ_CP117268:467547-467786 [Rhizobium rhododendri]
ATGGCATCTATCACGATCCGAAACGTGCCCGACGAAGTGCATCGGGCGCTTCGGGTGCGCGCTGCTCAGCACGGTCGCAG
CGCCGAGGCGGAAATTCGCATCATCCTGGAACAGGCCGCCAAGCCGGAAGGCCGAGTCAAACTCGGCAGCCTGCTCACAC
AAATAGGCCAGGAAGTCGGCGGCCTCGATCTGACGATCGAGCGAGACCGCACCCCGTCGCCGCCGGTGAGCTTTGAATGA
ATGGCATCTATCACGATCCGAAACGTGCCCGACGAAGTGCATCGGGCGCTTCGGGTGCGCGCTGCTCAGCACGGTCGCAG
CGCCGAGGCGGAAATTCGCATCATCCTGGAACAGGCCGCCAAGCCGGAAGGCCGAGTCAAACTCGGCAGCCTGCTCACAC
AAATAGGCCAGGAAGTCGGCGGCCTCGATCTGACGATCGAGCGAGACCGCACCCCGTCGCCGCCGGTGAGCTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|