22074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 813160..813926 Replicon chromosome
Accession NC_009456
Organism Vibrio cholerae O395

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VC0395_RS03680 Protein ID WP_000982260.1
Coordinates 813429..813926 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag VC0395_RS03675 Protein ID WP_000246253.1
Coordinates 813160..813432 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VC0395_RS03635 808388..809305 - 918 WP_000186333.1 alpha/beta hydrolase -
VC0395_RS03640 809539..809841 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
VC0395_RS03645 809829..810086 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VC0395_RS03650 810288..810821 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
VC0395_RS20930 810818..811243 - 426 WP_001882332.1 DUF1778 domain-containing protein -
VC0395_RS03660 811310..811681 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
VC0395_RS03665 811822..812109 - 288 WP_000426470.1 hypothetical protein -
VC0395_RS03670 812261..812929 - 669 WP_000043871.1 hypothetical protein -
VC0395_RS03675 813160..813432 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
VC0395_RS03680 813429..813926 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
VC0395_RS03685 814223..814717 + 495 WP_000477435.1 hypothetical protein -
VC0395_RS03695 815035..816693 + 1659 WP_001125478.1 recombinase family protein -
VC0395_RS03705 817180..817581 - 402 WP_012706059.1 hypothetical protein -
VC0395_RS03710 817596..817973 - 378 WP_000073388.1 hypothetical protein -
VC0395_RS19810 817990..818265 - 276 WP_000095573.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 782136..816693 34557
- inside Integron - - 799858..813432 13574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T22074 WP_000982260.1 NC_009456:813429-813926 [Vibrio cholerae O395]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T22074 NC_009456:813429-813926 [Vibrio cholerae O395]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT22074 WP_000246253.1 NC_009456:813160-813432 [Vibrio cholerae O395]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT22074 NC_009456:813160-813432 [Vibrio cholerae O395]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References