Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2405541..2406465 Replicon chromosome
Accession NZ_CP085390
Organism Cytobacillus firmus strain CK19

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag LIS77_RS12360 Protein ID WP_252222381.1
Coordinates 2405541..2406305 (+) Length 255 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag LIS77_RS12365 Protein ID WP_222500259.1
Coordinates 2406286..2406465 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS77_RS12340 (LIS77_12345) 2400609..2402576 + 1968 WP_252222159.1 hypothetical protein -
LIS77_RS12345 (LIS77_12350) 2402662..2403384 - 723 WP_252222162.1 hypothetical protein -
LIS77_RS12350 (LIS77_12355) 2403660..2404883 + 1224 WP_252222164.1 S8 family peptidase -
LIS77_RS12355 (LIS77_12360) 2404926..2405330 + 405 WP_222500264.1 hypothetical protein -
LIS77_RS12360 (LIS77_12365) 2405541..2406305 + 765 WP_252222381.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
LIS77_RS12365 (LIS77_12370) 2406286..2406465 + 180 WP_222500259.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
LIS77_RS12370 (LIS77_12375) 2406729..2408099 - 1371 WP_252222167.1 aldehyde dehydrogenase -
LIS77_RS12375 (LIS77_12380) 2408364..2409317 - 954 WP_222500255.1 nuclease-related domain-containing protein -
LIS77_RS12380 (LIS77_12385) 2409373..2410626 - 1254 WP_252222175.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(4-239)

Antitoxin

Antitoxin SpoIISB

(16-58)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29759.43 Da        Isoelectric Point: 4.5024

>T220736 WP_252222381.1 NZ_CP085390:2405541-2406305 [Cytobacillus firmus]
MLVFFKVSVWMIVACLGFYVISVWLWEKKVKERMPVIRKTWYILYVLGAVVYWSTKPDSIFANWQNYLIVAVIFALVDAF
VFLGSYLKRVGNNELATDTRELLEENSDLLNSHMNKLKSFQYLLKNEPIDIYYGNKEAYLAGIEKLLADFAEKVDMKIAL
CKYTAKEEKDFLLEHYTDKALIHSRLDRREVYYDAEEKLALIPFSILEDDYVIKLTSDQFVTEFDYLLFTSLISIYDLML
PAEQEDEANEGTSE

Download         Length: 765 bp

>T220736 NZ_CP117262:c155920-155501 [Rhizobium tumorigenes]
ATGATCTTGCTAGACACTAATGTAGTATCGGAGCCTTGGAAGCCGGCTCCTGATACTGCTGTGCTGACTTGGCTGGATGC
ACAGGCCATCGAGACGCTATTCATCTCTGCGATTTCAATTGCCGAACTTCGTTTCGGGATTGCCTCAATGCCCTCAGGAA
AGCGTCAGACAATTCTCCACGATCGCCTTGAAGGTGAAGTTCTTCCCATCTTTGACGGGCGCGTTCTGCCTTTTAACGTA
GGCACCGCGCAATTCTACGCGAAGCTGATGGCTAGCGCCCAAACATCAGGAAAGGCGATCGGGAAGGCTGATGGATACAT
TGCTGCTACGGCAGCAGAAAACCATCTCGCGGTCGCAACGCGAGATACAAGCCCATTTGAGGCAGCCGGAGTGAGAGTTA
TCAATCCTTGGGTCGCCTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6875.03 Da        Isoelectric Point: 11.2836

>AT220736 WP_222500259.1 NZ_CP085390:2406286-2406465 [Cytobacillus firmus]
MKEPANKKKNVPRIHSNNAMKTLQKRSRISLPGFEVSPHTERILKENERLISVYTKTKT

Download         Length: 180 bp

>AT220736 NZ_CP117262:c156171-155917 [Rhizobium tumorigenes]
GTGGCGGCTGTGACCATTCGAAACATCTCTGATGAAACGCATCGGGCATTACGCGCAAGAGCAACTCACCACGGCCGTAG
TACCGAGGCCGAAATTCGTGACATTCTTGAAGCCGCTGTTCGTCCATCTGGACGCGTGAAACTCGGATCATTGCTCGCGG
CCATTGGTCGTGATGCCAAACTGTCAGACAGTGACGTCGAAGCGCTGCAACAACAGCGCGACAGGACCCCGGCAGAACCG
ATGATTTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References