Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 257341..257977 Replicon chromosome
Accession NZ_CP085390
Organism Cytobacillus firmus strain CK19

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag LIS77_RS01395 Protein ID WP_009336311.1
Coordinates 257627..257977 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W7L1R3
Locus tag LIS77_RS01390 Protein ID WP_035331931.1
Coordinates 257341..257622 (+) Length 94 a.a.

Genomic Context

LIS77_RS01375LIS77_RS01380LIS77_RS01385LIS77_RS01390LIS77_RS01395LIS77_RS01400LIS77_RS01405LIS77_RS01410LIS77_RS01415LIS77_RS01420LIS77_RS01425LIS77_RS01430LIS77_RS01370
Location: 253627..253980 (354 bp)
Type: Others
Protein ID: WP_222501764.1
Location: 254125..255138 (1014 bp)
Type: Others
Protein ID: WP_197212719.1
Location: 255720..256874 (1155 bp)
Type: Others
Protein ID: WP_252220618.1
Location: 257341..257622 (282 bp)
Type: Antitoxin
Protein ID: WP_035331931.1
Location: 257627..257977 (351 bp)
Type: Toxin
Protein ID: WP_009336311.1
Location: 258350..259183 (834 bp)
Type: Others
Protein ID: WP_163144748.1
Location: 259180..259542 (363 bp)
Type: Others
Protein ID: WP_009336309.1
Location: 259547..259948 (402 bp)
Type: Others
Protein ID: WP_048008772.1
Location: 259960..260970 (1011 bp)
Type: Others
Protein ID: WP_252220620.1
Location: 261031..261363 (333 bp)
Type: Others
Protein ID: WP_035331808.1
Location: 261360..261833 (474 bp)
Type: Others
Protein ID: WP_009336304.1
Location: 261811..262605 (795 bp)
Type: Others
Protein ID: WP_252220622.1
Location: 252746..253471 (726 bp)
Type: Others
Protein ID: WP_222501762.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LIS77_RS01370 (LIS77_01370)252746..253471-726WP_222501762.1rhomboid family intramembrane serine protease-
LIS77_RS01375 (LIS77_01375)253627..253980+354WP_222501764.1holo-ACP synthase-
LIS77_RS01380 (LIS77_01380)254125..255138+1014WP_197212719.1outer membrane lipoprotein carrier protein LolA-
LIS77_RS01385 (LIS77_01385)255720..256874+1155WP_252220618.1alanine racemase-
LIS77_RS01390 (LIS77_01390)257341..257622+282WP_035331931.1YlcI/YnfO family proteinAntitoxin
LIS77_RS01395 (LIS77_01395)257627..257977+351WP_009336311.1type II toxin-antitoxin system endoribonuclease NdoAToxin
LIS77_RS01400 (LIS77_01400)258350..259183+834WP_163144748.1RsbT co-antagonist protein RsbRA-
LIS77_RS01405 (LIS77_01405)259180..259542+363WP_009336309.1STAS domain-containing protein-
LIS77_RS01410 (LIS77_01410)259547..259948+402WP_048008772.1anti-sigma regulatory factor-
LIS77_RS01415 (LIS77_01415)259960..260970+1011WP_252220620.1PP2C family protein-serine/threonine phosphatase-
LIS77_RS01420 (LIS77_01420)261031..261363+333WP_035331808.1anti-sigma factor antagonist-
LIS77_RS01425 (LIS77_01425)261360..261833+474WP_009336304.1anti-sigma B factor RsbW-
LIS77_RS01430 (LIS77_01430)261811..262605+795WP_252220622.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T220735 WP_009336311.1 NZ_CP085390:257627-257977 [Cytobacillus firmus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

>T220735 NZ_CP117261:2705779-2706069 [Rhizobium tumorigenes]
ATGGTTGAGAAATTAACCCCTTACGACCCAGCCGAAGATCTCGTCTCGGATGAGGCAATGGCAGTCTTCATGGGCGAAGC
GTTCGAGACGGGCGATGCCGGCTATATCGCCCACGCCCTTGGCGTGGTCGCGCGTGCAAAAGGCATGACGCAGATTGCCA
CCGACACCGGCCTGTCGCGGGAGCAACTCTACAGGTCTTTCAGTGAGGCGGGAAATCCAACCCTTAAGACAACGATGGCA
GTGATGAAGGCGCTCGGCATTACCCTCACCGCGAAGGTCGCAGCCGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10831.33 Da        Isoelectric Point: 7.2028

>AT220735 WP_035331931.1 NZ_CP085390:257341-257622 [Cytobacillus firmus]
VSESSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT220735 NZ_CP117261:2705481-2705786 [Rhizobium tumorigenes]
ATGTTGGAGCTGCGGCAAACAGCCGCTTTCGCAAAGTGGCGACAACGCCTGACCGATGACCGGGCCCGTGCCATAATCGC
CTCACGGCTCGACAGGCTTGCCTATGGCCACAGTGGCGACGCGCAGTCCGTCGGCGATGGCGTTCAGGAGCTTCGAATTC
AATATGGCCCCGGCTACCGCATATATTTTAAAACACGCGGCAACACGCTGATCATCCTGCTGTGCGGCAGCGACAAAAGC
ACGCAGGCAAGAGACATCAGCGCCGCAAAGCGCCTGCTGACGGAGTGGAGTGACGACCATGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A169FD46

Antitoxin

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Source
ID
Structure
AlphaFold DBW7L1R3

References