Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1841243..1841885 Replicon chromosome
Accession NZ_CP085345
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LIN44_RS24695 Protein ID WP_092314543.1
Coordinates 1841709..1841885 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LIN44_RS24690 Protein ID WP_092314545.1
Coordinates 1841243..1841659 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS24665 (LIN44_24665) 1836615..1837532 + 918 WP_227314880.1 cysteine synthase A -
LIN44_RS24670 (LIN44_24670) 1837568..1838704 - 1137 WP_227314881.1 BamA/TamA family outer membrane protein -
LIN44_RS24675 (LIN44_24675) 1838718..1839818 - 1101 WP_227314882.1 hypothetical protein -
LIN44_RS24680 (LIN44_24680) 1839975..1840463 - 489 WP_227314883.1 GFA family protein -
LIN44_RS24685 (LIN44_24685) 1840548..1841210 - 663 WP_227314884.1 DNA oxidative demethylase AlkB -
LIN44_RS24690 (LIN44_24690) 1841243..1841659 - 417 WP_092314545.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LIN44_RS24695 (LIN44_24695) 1841709..1841885 - 177 WP_092314543.1 type II toxin-antitoxin system HicA family toxin Toxin
LIN44_RS24700 (LIN44_24700) 1842079..1843518 - 1440 WP_227314885.1 flagellar hook-length control protein FliK -
LIN44_RS24705 (LIN44_24705) 1843570..1844028 - 459 WP_227314886.1 flagellar export protein FliJ -
LIN44_RS24710 (LIN44_24710) 1843994..1845490 - 1497 WP_227314887.1 flagellar protein export ATPase FliI -
LIN44_RS24715 (LIN44_24715) 1845483..1846295 - 813 WP_227314888.1 flagellar assembly protein FliH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(87-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6493.49 Da        Isoelectric Point: 11.5631

>T220731 WP_092314543.1 NZ_CP085345:c1841885-1841709 [Cupriavidus sp. MP-37]
VKQSEFRRWLAGQGATFIEGAKHVRVYLNGRQSTLPRHPSHEIGEGLRKAILKQLGLG

Download         Length: 177 bp

>T220731 NZ_CP117261:1522386-1522691 [Rhizobium tumorigenes]
GTGTTCGTTATCCAGCGCACCGAAATCTTCCAGCAGTGGATTATGCGACTGAAGGATCGTCGCGCCGCCGCTCGCATTGC
ATCGCGCATTTTGCGCGCGGAAGATGGTAACCTGGGTGACGTCAAACCTGTCGGAGATGGCGTCGAGGAAATGCGTATCG
ACTACGGGCCGGGCTACAGGATCTATTTCCTCAGACGGCGCTCGGTGCTTGTCGTTCTTCTCGTCGGCGGCGACAAGAGC
ACACAGCGAAGAGACATCATCGAAGCAAAGCGCCTTTGTGCAGAATGGAGGGAGCGCAACCAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15117.42 Da        Isoelectric Point: 5.6212

>AT220731 WP_092314545.1 NZ_CP085345:c1841659-1841243 [Cupriavidus sp. MP-37]
MLRFPANIVPDGDGFAVSFPDIPEALTSGDTIEHAQEMAADALATAMEFYFEDGRPVPLPSKAVRGQHLVELPASMSAKV
LLLNEMIAQGVTQAELARRLHTRKQEVQRIVNLDHATKIDTIEAAFRALGKRLELKVA

Download         Length: 417 bp

>AT220731 NZ_CP117261:1522688-1522990 [Rhizobium tumorigenes]
ATGACTTCAGATACCAGACTTTTCGACGCTTCCGAGGTTCTCGACAACGAGAGTGCGGTCGACGAATTTCTCGCCGCGGC
GTTCGAAACCGAGGACCCGGCCTTCATCGCCAAAAGTCTTGGTGTGATTGCTAAAACCCGAAACATGAGCGCTCTCGCCC
GCGATGTCGGAATGAGCCGAGCTGCCCTCTACAAATCGCTGAGCGGCGAAGGCAATCCGGAATTTGCGACCATTATCAAG
GTTATGAAGGCACTTGGCCTCGGCCTTGCTCCAGTCTCGCGGTCCAACCAGGGCGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References