Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 424402..424985 Replicon chromosome
Accession NZ_CP085345
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LIN44_RS18460 Protein ID WP_227315713.1
Coordinates 424605..424985 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LIN44_RS18455 Protein ID WP_227315712.1
Coordinates 424402..424608 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS18435 (LIN44_18435) 419787..420692 + 906 WP_227315709.1 MurR/RpiR family transcriptional regulator -
LIN44_RS18440 (LIN44_18440) 420695..422149 + 1455 WP_227315710.1 D-aminoacylase -
LIN44_RS18445 (LIN44_18445) 422202..422594 + 393 WP_012355941.1 RidA family protein -
LIN44_RS18450 (LIN44_18450) 422829..424190 + 1362 WP_227315711.1 GntP family permease -
LIN44_RS18455 (LIN44_18455) 424402..424608 + 207 WP_227315712.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LIN44_RS18460 (LIN44_18460) 424605..424985 + 381 WP_227315713.1 type II toxin-antitoxin system VapC family toxin Toxin
LIN44_RS18465 (LIN44_18465) 425071..425988 + 918 WP_227315714.1 aldo/keto reductase -
LIN44_RS18470 (LIN44_18470) 426001..427377 + 1377 WP_227315715.1 MFS transporter -
LIN44_RS18475 (LIN44_18475) 427538..428644 + 1107 WP_227315716.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
LIN44_RS18480 (LIN44_18480) 428658..429500 + 843 WP_227315717.1 S-formylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13764.02 Da        Isoelectric Point: 7.3232

>T220729 WP_227315713.1 NZ_CP085345:424605-424985 [Cupriavidus sp. MP-37]
MSVLVDTSVWVSHFRHRNDALIRLMEADQVLIHPMVVAELACGTPPAPRAQTLGDLGLLQAARQATQAEVIALVEREQLY
GLGCGLVDVTLLASTLITPGARLWTLDQRLNALSARFGVGYRPRLH

Download         Length: 381 bp

>T220729 NZ_CP117261:c971251-970955 [Rhizobium tumorigenes]
ATGCCCTTGGAAACCACCCACTTTGACATCCAGGACCATTTGGCCACACCGGCCGACCGCATGCTCTATCTCGAAGCCGC
TTTCGAGGACGGTGATCCGGCGCTCATCGCCCAGGCCCTCGGCGACGTTGCCCGTGCTGCCGGCATGACGTCTGTCGCCA
AGGAAGCGGGCGTGACCCGGGAGGCGCTTTATAAATCACTGAGCGAAGCCGGTGATCCGCGACTGTCAACGTTTCTCGGC
GTGATCAAGGCGCTGGGCTTGAAAGTGTCGATTGCGGCAGATCAGAATGCCGCGTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7503.61 Da        Isoelectric Point: 4.6920

>AT220729 WP_227315712.1 NZ_CP085345:424402-424608 [Cupriavidus sp. MP-37]
MRTTVTIDDALYEQALEMADPGMDKADLFREAIKTFVRVQAAKRLAALGGAAPDMQDIPRRSPEPDVK

Download         Length: 207 bp

>AT220729 NZ_CP117261:c971542-971252 [Rhizobium tumorigenes]
GTGATCGAAGTTCGGCAGACCGCTATCTTTGCGAATTGGCTCGATGCGCTCCGAGACGCGCAGGCGCGCCAACGCATCGT
CGTTCGCATCCGGCGGCTCGAACTCGGTAACCCTGGAGATATCAAGCCGGTCGGTGAAGGTGTCAGCGAAATGCGCATCC
CCCATGGCCCCGGCTACAGGCTCTATTTCACCCGATCCGGTGCGACGATCGTCATTCTTTTATGCGGCGGCGACAAGTCA
TCGCAGGCAAGGGACATCGCAATCGCCCGGCAATTGGCTAAGGAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References