220728

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-TIGR02293
Location 377286..378271 Replicon chromosome
Accession NZ_CP085345
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name ParT Uniprot ID -
Locus tag LIN44_RS18230 Protein ID WP_227315675.1
Coordinates 377286..377759 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID -
Locus tag LIN44_RS18235 Protein ID WP_227315676.1
Coordinates 377756..378271 (-) Length 172 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS18205 (LIN44_18205) 372392..372727 + 336 WP_227315672.1 cupin domain-containing protein -
LIN44_RS18210 (LIN44_18210) 372735..373619 - 885 WP_227315673.1 LysR family transcriptional regulator -
LIN44_RS18215 (LIN44_18215) 373739..374170 + 432 WP_227315674.1 VOC family protein -
LIN44_RS18220 (LIN44_18220) 374194..374517 - 324 WP_062803140.1 thioredoxin family protein -
LIN44_RS18225 (LIN44_18225) 374683..376989 - 2307 WP_227316453.1 ATP-dependent DNA helicase -
LIN44_RS18230 (LIN44_18230) 377286..377759 - 474 WP_227315675.1 RES family NAD+ phosphorylase Toxin
LIN44_RS18235 (LIN44_18235) 377756..378271 - 516 WP_227315676.1 DUF2384 domain-containing protein Antitoxin
LIN44_RS18240 (LIN44_18240) 378367..379326 - 960 WP_227315677.1 DNA-binding protein -
LIN44_RS18245 (LIN44_18245) 379440..380561 + 1122 WP_227315678.1 site-specific integrase -
LIN44_RS18250 (LIN44_18250) 380804..381229 + 426 WP_092316998.1 hypothetical protein -
LIN44_RS18255 (LIN44_18255) 381527..381865 - 339 WP_227315679.1 hypothetical protein -
LIN44_RS18260 (LIN44_18260) 382188..382832 - 645 WP_227315680.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(4-151)

Antitoxin

Antitoxin Xre

(37-171)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 16958.31 Da        Isoelectric Point: 7.2759

>T220728 WP_227315675.1 NZ_CP085345:c377759-377286 [Cupriavidus sp. MP-37]
MKPAWRIATDTPAYTADDASGAGARATGGRWNRQGTPLIYAASSIALACLETLVHLGSAGLPLNRYLVRIDIPDDLWAAA
RHLTAASAPVGWDAIPAGKTSLDTGEDWVREGTSALLLVPSIVVPEEFNVLVNPLHADARRLVYTKVRRWQYDARLA

Download         Length: 474 bp

>T220728 NZ_CP117261:621250-621495 [Rhizobium tumorigenes]
ATGAGGGACGTTGTCGTATCCAGGCTTGCCGACAAAGCGCTTATGCGCATGCAGCCAAAACGGCGGCTGGCGATCATTGA
AAAAGTCAAAGCCTATGCGCGCGGAGAGATTGTCGACATCAAGAAGATGAAGGGCGGAAATCTCTACCGTATCAGGGTCG
GACAGGATCGCGTCATCATCGACGACAAGGGTAGGATTGTCGTGGTCATCGATGCCGGTCCGCGGGGCAGTATCTACAAG
GAGTGA

Antitoxin


Download         Length: 172 a.a.        Molecular weight: 18632.23 Da        Isoelectric Point: 8.5033

>AT220728 WP_227315676.1 NZ_CP085345:c378271-377756 [Cupriavidus sp. MP-37]
MPRMLTPKGHYPLAAERRPARELSLNSYLAVYEATLSTEGAMSVIHAIREGVPASDLNRLAESMGTSKEQLIKTLDLPRA
TVDRKARAHQNLSSEQSERVLGMVRLVGQVQALVESSGDPRGFNAPQWVAQWLEQPSPALGGQRPAELMDTVAGQRIVSD
LVARMQSGAYA

Download         Length: 516 bp

>AT220728 NZ_CP117261:621502-621864 [Rhizobium tumorigenes]
ATGGGCGATATCAAGAGGTTCGAAATCGACGGCAAACCCTACGTGCTGTTGAGTGAAGAGGATTACGAGGATCTGGTCGA
TGGACTGAGAGCGAATGCTGTCCTGGCCGGGATTTCTGCAGGAGAAGAAACCTGGCCCTTGGAGATCGTTGAGGCGCGTG
CCAATGGCGGGAATGCCGTTCGTATATTCCGAAACTACCGTCGCATGACTGTCACCGAACTTGCGACGGCCGCCGGAATT
TCGCAGCCTTATCTCTCTGAGATCGAGGCAGGCAAAAAAACCGGCAGTGTCGATGTGCTGAAGCGTATCGCTACCGCCCT
CAAGGTCGATCTCGACGATCTCGTCGTCGACGTGGCGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References