220727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2564109..2564802 Replicon chromosome
Accession NZ_CP085344
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag LIN44_RS11815 Protein ID WP_227312242.1
Coordinates 2564109..2564486 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag LIN44_RS11820 Protein ID WP_227312243.1
Coordinates 2564467..2564802 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS11795 (LIN44_11795) 2561154..2561516 - 363 WP_227312239.1 RidA family protein -
LIN44_RS11800 (LIN44_11800) 2561568..2562446 - 879 WP_227312240.1 alpha/beta hydrolase -
LIN44_RS11805 (LIN44_11805) 2562651..2563427 + 777 WP_112775421.1 3-hydroxybutyrate dehydrogenase -
LIN44_RS11810 (LIN44_11810) 2563444..2563932 + 489 WP_227312241.1 DUF411 domain-containing protein -
LIN44_RS11815 (LIN44_11815) 2564109..2564486 + 378 WP_227312242.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN44_RS11820 (LIN44_11820) 2564467..2564802 + 336 WP_227312243.1 helix-turn-helix transcriptional regulator Antitoxin
LIN44_RS11825 (LIN44_11825) 2564871..2565509 - 639 WP_227312244.1 CoA transferase subunit B -
LIN44_RS11830 (LIN44_11830) 2565522..2566223 - 702 WP_012352543.1 CoA transferase subunit A -
LIN44_RS11835 (LIN44_11835) 2566405..2566950 + 546 WP_116356249.1 PAS and helix-turn-helix domain-containing protein -
LIN44_RS11840 (LIN44_11840) 2567186..2567587 - 402 WP_227312245.1 acyl-CoA thioesterase -
LIN44_RS11845 (LIN44_11845) 2567640..2568668 - 1029 WP_227312246.1 DctP family TRAP transporter solute-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14157.42 Da        Isoelectric Point: 10.4690

>T220727 WP_227312242.1 NZ_CP085344:2564109-2564486 [Cupriavidus sp. MP-37]
MPAKERPLFWIGRSRKDLTELPLDVRRFFGHALHFAQRGDRHDAAKILKGFGSAGVLEILEDDAAGTYRAVYTVKFAEAV
FVLHCFQKKSKRGIATPKADIEIIRARLKVAEALAWELRHGKTQD

Download         Length: 378 bp

>T220727 NZ_CP117261:501205-501477 [Rhizobium tumorigenes]
ATGGCGTGGAGGATTGAGTTCCAGCGGCCGGCGGAACGCGATCTTGAAAAGCTCGATCATGAGAGCGTGAAAAGGATACT
CCGTTTCCTTCACACGCGTGTCGCCAGTCTCGAGGACCCCCGGGCGATAGGGGAGGCGCTCCGCGGATCGGAACTTGGAA
ACTTCTGGAAGTATCGTGTTAGAGACTATCGCATCATTGCCGACATAGACGACGGCACTGTCCGGATATTGGTCGTCCGC
ATTGGCAATCGGAAGGACGTCTATCGCCGCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12020.01 Da        Isoelectric Point: 8.0410

>AT220727 WP_227312243.1 NZ_CP085344:2564467-2564802 [Cupriavidus sp. MP-37]
MAKRRIDGIEVEASSGNVFADLGVPEADKLKIKSGLAIEITRAVRSLGLTQEEAAHRMGIPQPKVSGLLRGDFANLSERK
LMDCLNRLGYDIEIKVSPALEPIGHLTLKVA

Download         Length: 336 bp

>AT220727 NZ_CP117261:500997-501221 [Rhizobium tumorigenes]
ATGCTTGCCCTGCGTTTGCCTCCTGACATCGAAGCAAGACTAGATGAGCTCGCCAAACGCACCGGGCGGAGCAAGAGCTT
CTATGCGCGTCAAGCGATATTGGAACACTTGGACGATCTGGAAGACCTCTACGTCGCCGAGCAGAGGCTCGAAGAATTCC
GTAGAGGCGACAGTGATAGCATTTCTCTCGCTGAATTGATGGCGCGCCATGGCGTGGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References