Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2449035..2449629 Replicon chromosome
Accession NZ_CP085344
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LIN44_RS11285 Protein ID WP_227312161.1
Coordinates 2449035..2449325 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LIN44_RS11290 Protein ID WP_227312162.1
Coordinates 2449339..2449629 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS11265 (LIN44_11265) 2444393..2445004 - 612 WP_227312157.1 hypothetical protein -
LIN44_RS11270 (LIN44_11270) 2445013..2446197 - 1185 WP_227312158.1 acetyl-CoA C-acyltransferase family protein -
LIN44_RS11275 (LIN44_11275) 2446313..2447692 - 1380 WP_227312159.1 30S ribosomal protein S12 methylthiotransferase RimO -
LIN44_RS11280 (LIN44_11280) 2447847..2448815 - 969 WP_227312160.1 tRNA-dihydrouridine synthase -
LIN44_RS11285 (LIN44_11285) 2449035..2449325 + 291 WP_227312161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN44_RS11290 (LIN44_11290) 2449339..2449629 + 291 WP_227312162.1 putative addiction module antidote protein Antitoxin
LIN44_RS11295 (LIN44_11295) 2449683..2450234 - 552 WP_012352635.1 polyhydroxyalkanoate synthesis repressor PhaR -
LIN44_RS11300 (LIN44_11300) 2450655..2451395 - 741 WP_227312163.1 3-ketoacyl-ACP reductase -
LIN44_RS11305 (LIN44_11305) 2451467..2452648 - 1182 WP_227312164.1 acetyl-CoA C-acetyltransferase -
LIN44_RS11310 (LIN44_11310) 2452734..2454515 - 1782 WP_227312165.1 class I poly(R)-hydroxyalkanoic acid synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10584.12 Da        Isoelectric Point: 8.7510

>T220726 WP_227312161.1 NZ_CP085344:2449035-2449325 [Cupriavidus sp. MP-37]
MLSIRTTQTFDRWYAALRDSAARIRIQVRIDRMLNGNPGDVKALGGGICEMRVDHGPGYRIYFQRCGEVLVILLCGGDKS
TQHADIGRGTPHGGEP

Download         Length: 291 bp

>T220726 NZ_CP117261:404238-404522 [Rhizobium tumorigenes]
ATGGCAATTCTTTCGTTCAAGGATGGGTCGACGCGCGCAGTTGCTTCCGGCGCTGTGCCGAAAGGCTTTCCCGCCGACCT
TGCGCGACGTGCTATTCGCAAGCTGACTATGATCGAATTTGCCAACCAGCTTTCGGACCTACGTTCGCCGCCCGCAAATC
ATCTCGAGGCGTTGAAGGGAGATCGTGCAGGCCAACATTCCATCCGCATCAACGATCAATGGCGGATTTGCTTCGTCTGG
ACCGATGCTGGCGTCGAAGATGTCGAAATTGTCGATTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10586.00 Da        Isoelectric Point: 6.9800

>AT220726 WP_227312162.1 NZ_CP085344:2449339-2449629 [Cupriavidus sp. MP-37]
MKEPTRPWDSAAQLRNETEIAAYLDTCLAEAGDDDRFIAYALGVVARARGMTRLARETGLSRESLYRSLSGEGNPEFGTI
WKVMRALGIRLHASVG

Download         Length: 291 bp

>AT220726 NZ_CP117261:404533-404829 [Rhizobium tumorigenes]
ATGAAGCACATTCTTCCACCGGTGCATCCGGGTGAAATCCTTCGGGAGGAGTATCTGGCGCCGCTTGAAATGAGCGCCGG
CGCCCTCGCGCGCAAGCTGAACGTCCCGCGAACGCGCATCGAGCGTCTGGTCGCCGAGGAAACGCCGGTGACCATCGATA
CCGCGTTGCGGTTGGCCCGCTTTTTCGACACGACGCCGGAGTTCTGGATGAATATGCAAACTGGCTACGAACTGAAGCGC
CAAGCGGAGGAAAAAAGAGCCGAGATCGCCGCTATCCCAGTCCTCCATGTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References