Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 1827828..1828390 Replicon chromosome
Accession NZ_CP085344
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LIN44_RS08590 Protein ID WP_116356652.1
Coordinates 1827828..1828148 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LIN44_RS08595 Protein ID WP_227311803.1
Coordinates 1828142..1828390 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS08565 (LIN44_08565) 1822925..1824010 + 1086 WP_227311799.1 mechanosensitive ion channel -
LIN44_RS08570 (LIN44_08570) 1824041..1824925 - 885 WP_227311800.1 metal-dependent hydrolase -
LIN44_RS08575 (LIN44_08575) 1824934..1826487 - 1554 WP_227311801.1 serine hydrolase -
LIN44_RS08585 (LIN44_08585) 1826815..1827624 - 810 WP_227311802.1 MetQ/NlpA family ABC transporter substrate-binding protein -
LIN44_RS08590 (LIN44_08590) 1827828..1828148 - 321 WP_116356652.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LIN44_RS08595 (LIN44_08595) 1828142..1828390 - 249 WP_227311803.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LIN44_RS08600 (LIN44_08600) 1828557..1828964 - 408 WP_227311804.1 VOC family protein -
LIN44_RS08605 (LIN44_08605) 1829205..1829675 + 471 WP_227314364.1 SRPBCC family protein -
LIN44_RS08610 (LIN44_08610) 1829672..1831153 + 1482 WP_227311805.1 DHA2 family efflux MFS transporter permease subunit -
LIN44_RS08615 (LIN44_08615) 1831174..1831443 - 270 WP_012353003.1 acyl-CoA-binding protein -
LIN44_RS08620 (LIN44_08620) 1831573..1832328 + 756 WP_227311806.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB -
LIN44_RS08625 (LIN44_08625) 1832325..1832885 + 561 WP_227311807.1 ribosomal protein S18-alanine N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11802.79 Da        Isoelectric Point: 10.4426

>T220723 WP_116356652.1 NZ_CP085344:c1828148-1827828 [Cupriavidus sp. MP-37]
MVARGDVWLVALDPTVGSEIEKTRPCVILSPPEMHDYLRTVTVAPMTTGSRPAPFRIPVTFQRKTGLILLDQLRTVDKSR
LVKRAGGLSERTVADTLRTLREVFAD

Download         Length: 321 bp

>T220723 NZ_CP117261:160116-160445 [Rhizobium tumorigenes]
ATGGAGCGAGGTGAGATATGGTTTGTCGATCTGGAGCCGACACGCGGGCGCGAGCAAGCGAATGAGCGTTACGCTATGAT
CTTGTCCCCGAAGGTCGTCAACCAGCACGGAACCCAGATCGTCGCGCCTATCACCACCGGCGGTCAGTTTGCCAGGACGT
CCGGCTTTGCGGTCTCGCTATCAGGCGCTGGAACGCGATCGACGGGAGTGGTGCTGTGCCACCAGATCCGCGCCGTCGAT
ATCAAAGCAAGACGGGGCCGTTTCGTGGAGAAGGCACCAGACTTCATCGTTGACGAGGTCTTGGCCAGGGTCGCGGCGCT
ATTCGACTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8960.26 Da        Isoelectric Point: 4.7205

>AT220723 WP_227311803.1 NZ_CP085344:c1828390-1828142 [Cupriavidus sp. MP-37]
MKATIRKMGNSQGVLIPKAILAQLGLEHEVEMEIVNDTLVLRRPRQAPRQGWAEASQQIAAAGDDSLVLGDLPNADDAEL
KW

Download         Length: 249 bp

>AT220723 NZ_CP117261:159856-160116 [Rhizobium tumorigenes]
ATGGTGGCATCGACTTTGCGCAACGTTGGCGGCTCCTTGGTGATGACTGTCCCAAAAGCCATCACGGACGAGCTCGGCCT
CCATGCCAACACCAAATTCGACGTGATTGCACAGGATGGAAACATCATTGCCGTGCCGCGCCGCAGGCCAAAATACACAG
TCGAGCAGCTCGTGGCCGAATGGGAGGTTTGGCCTGAACGGACAGCCGAGGAACAGGAGTGGCTCGATATACCATCTGTT
GGCAACGAGATTATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References