Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1109806..1110445 Replicon chromosome
Accession NZ_CP085344
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LIN44_RS05210 Protein ID WP_227313813.1
Coordinates 1109806..1110222 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LIN44_RS05215 Protein ID WP_227313814.1
Coordinates 1110209..1110445 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS05190 (LIN44_05190) 1105418..1105777 + 360 WP_227313811.1 hypothetical protein -
LIN44_RS05195 (LIN44_05195) 1105833..1106663 + 831 WP_116370449.1 formate dehydrogenase accessory sulfurtransferase FdhD -
LIN44_RS05200 (LIN44_05200) 1106758..1107324 + 567 WP_018008077.1 dCTP deaminase -
LIN44_RS05205 (LIN44_05205) 1107472..1109742 + 2271 WP_227313812.1 arginine/lysine/ornithine decarboxylase -
LIN44_RS05210 (LIN44_05210) 1109806..1110222 - 417 WP_227313813.1 type II toxin-antitoxin system VapC family toxin Toxin
LIN44_RS05215 (LIN44_05215) 1110209..1110445 - 237 WP_227313814.1 DNA-binding protein Antitoxin
LIN44_RS05220 (LIN44_05220) 1110689..1111387 - 699 WP_227313815.1 glutathione S-transferase family protein -
LIN44_RS05225 (LIN44_05225) 1111514..1112428 + 915 WP_227313816.1 LysR substrate-binding domain-containing protein -
LIN44_RS05230 (LIN44_05230) 1112490..1114208 - 1719 WP_227313817.1 TRAP transporter large permease subunit -
LIN44_RS05235 (LIN44_05235) 1114221..1114820 - 600 WP_227313818.1 TRAP transporter small permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15294.58 Da        Isoelectric Point: 10.3883

>T220722 WP_227313813.1 NZ_CP085344:c1110222-1109806 [Cupriavidus sp. MP-37]
VYLIDTNVISETRKRERANPGVRAFFREAAREGAALYLSALTVGELQRGVALIRQRGDAVQAALLERWLANVLEDFGRQV
LPVDAEVAQVWGQLRAARPEHALDKFIAATALIHRLTIVTRNVADFRGTGTMVLNPFS

Download         Length: 417 bp

>T220722 NZ_CP117256:c755597-754335 [Rhizobium tumorigenes]
ATGACGGTAAGGGTCCTTAACGTCTGGTGGAATGGTCGCATTGTCGGACAGTTCACCCAAGATCAGCACGGCGACATTGG
CTTCGCCTACGCCGAAGCTTGGCTTGAGGACGAAAAGGCACTTCCGCTTTCTGTCTCCCTACCGAAGCGTCCAGAGCGTT
TCTCTCGCCGTGAATGCCGCCCATTTTTCGGCGGCCTACTGCCAGAGGAAAGCCAGCGTCTGGTTGCGGCGCAGGCGTTG
GGTGTTTCACCTGCCAACGACTTCGCCCTTCTTGATCGCTTGGGCGGCGACGTCGCCGGCGCGCTTCAACTTTTGCCCGA
AGACCAGGAACCGATTGGAGGGGGCCTGATTGCCGATCGGCAATCAGCAGCTCTCGATGAGGCCGGAATCGTCCGGATAC
TGGACGCACTTCCGACGAGGCCGCTCTTGGCCGGCCAGGAAGGCTTGAGGCTATCGCTCGCGGGCGCCCAATCAAAAGCT
CCAGTTGTTCTCATCGATGGCCAAGTCGCACTTCCCTTACCAGGCCAGGCGACGACGCACATCTTGAAGCCACCGATTGC
GCGCTTTCCAGGGACGACCGAGAATGAAGCCTTTGCGATGAGGCTTGCTGCCGCAATCGGGCTCGACGTTGCTCCCGTCG
ACCCGAGGTCCGCGAATGGTCGCCCTTTCCTTTTGGTCAACAGATACGATCGCCACCACGATGGCGACGGTGTGGTTCTC
CGCATCCATCAAGAAGACTTCTGCCAAGCGCTGGGTGTGCCACCTGAAACAAAGTATGCAAGCGAGGGGGGGCCGACCTT
CAAGGATTGCTTCGAGCTGTTGCGTTGGGTCTCTGCGCGGCCGGGCACGGACATCGCTAAGCTTTTGGACGCTGCGATTT
TCAATCTCGTCATCGGAAATGCGGATGCTCACGGTAAGAATTTCTCGATCCTCTATGACCATTCTGGACCTAGGATGGCT
CCGCTGTACGACCTGCTTTCCACCGTGGCCTATCCAGATTGTTCCCCGAAATTGGCTATGCGGATCGGCAAACGCGCGAC
GCTTGCTGACATGGACGCTGATGGCTGGCAGGCTTTCTCGAAGGAGACAGGTGTCAGCTTACCTTTAGTGCGCCGTCGGG
TGAAAGAACTGACGGATGCCACAGGGGACGCTATCCCCCGGTTATTGGAAGATATGTCCCCACTTGCCGCAGATCCTGTG
TCGTTAAATCGCGTAGCGGCTTTGATCGCAGACCGTGCCAAACTCGTGGCCCTGAGCATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8380.38 Da        Isoelectric Point: 4.7361

>AT220722 WP_227313814.1 NZ_CP085344:c1110445-1110209 [Cupriavidus sp. MP-37]
MATLLVRGIDEALVQRLREQAAANGRSAEAEHRAILAQALGGTARRSFAEVLSSMPEVGQDADFARIQDTGEAPRVFD

Download         Length: 237 bp

>AT220722 NZ_CP117256:c755824-755594 [Rhizobium tumorigenes]
ATGGCAAAACAAGTTAGCAGTCCAGCCGAGATCGGCGCCCTGGTCCGCAGCACACGCAAGGCGCAAAACTTGCGGCAGGA
CGAGCTTGCTGGCGTTTCTGGCGTCGGCCTGCGGTTTATCGTCGATCTCGAAGCCGGCAAACCGACAGCACAGATCGGAA
AGGTCTTGCAGGTTTTACAAACGCTCGGTTGTTCGATTGATATTCTAGCCCCAGGTGAACGTAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References