Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 387250..387850 Replicon chromosome
Accession NZ_CP085344
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag LIN44_RS01775 Protein ID WP_227313296.1
Coordinates 387250..387519 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID -
Locus tag LIN44_RS01780 Protein ID WP_227313297.1
Coordinates 387503..387850 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS01755 (LIN44_01755) 382644..383780 - 1137 WP_227313293.1 ABC transporter substrate-binding protein -
LIN44_RS01760 (LIN44_01760) 383979..385451 + 1473 WP_227313294.1 oxygen-independent coproporphyrinogen III oxidase -
LIN44_RS01765 (LIN44_01765) 385525..386418 - 894 WP_227313295.1 c-type cytochrome -
LIN44_RS01775 (LIN44_01775) 387250..387519 + 270 WP_227313296.1 BrnT family toxin Toxin
LIN44_RS01780 (LIN44_01780) 387503..387850 + 348 WP_227313297.1 BrnA antitoxin family protein Antitoxin
LIN44_RS01785 (LIN44_01785) 388059..388874 + 816 WP_227313298.1 MipA/OmpV family protein -
LIN44_RS01790 (LIN44_01790) 388903..389307 + 405 WP_112777111.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
LIN44_RS01795 (LIN44_01795) 389320..390198 - 879 WP_183300789.1 protease HtpX -
LIN44_RS01800 (LIN44_01800) 390324..390737 - 414 WP_227313299.1 hypothetical protein -
LIN44_RS01805 (LIN44_01805) 390949..391380 + 432 WP_227313300.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
LIN44_RS01810 (LIN44_01810) 391896..392315 + 420 WP_227313301.1 nucleoside diphosphate kinase regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-107)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10348.68 Da        Isoelectric Point: 5.7172

>T220721 WP_227313296.1 NZ_CP085344:387250-387519 [Cupriavidus sp. MP-37]
MLIEFDAAKDRANQAKHGISLAAAEWFEWDCAVFDPDTRFEYAEERFQGLGLIGNRVHMVVFTVRGDSIRIISLRKANQR
EEKRYVDQT

Download         Length: 270 bp

>T220721 NZ_CP117256:747749-748171 [Rhizobium tumorigenes]
ATGAGACTGCTCCTCGACACCAATGTTCTGTCCGAAGTTACAAAACTTCGCCCCACTGAACGTGTCTTGAATTGGCTTCA
CGGACTTGATGAAGATCGCACATTCATCAGCATAGTCTCGATTGCCGAAATCCGTCGCGGCGTTGCGCTGATGGAGATTG
GGCGAAAGCGCGACGCCCTTGACGCGTGGCTTACGCATGATCTGCCCCAACGTTTCGAAAACAGGATTATTCCGGTGGAT
GGGCATGTTACCTTGGCTTGGGGTGATCTCATGGCTCTCGCCAAGCAAAGCGGTCGGGGACTTGCATCCATGGACGGTCT
GATCGCGGCCACCGCCGTCGCTTGCAATCTGACGCTTGCGACGCGCAACACAAAGGATTTCGAAGGCTTCGGAATAGACC
TCGTTGACCCATGGGCGGTCTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13155.06 Da        Isoelectric Point: 10.6282

>AT220721 WP_227313297.1 NZ_CP085344:387503-387850 [Cupriavidus sp. MP-37]
MSTKRKIVRVTDAEDVAIRRAAASDPDARELTDAELARMRPAREVLPRILGKEKAEALMKRRGRPALPEEERKVSVNVRY
DRDVIDAFKATGDGWQTRINEALRDYAKSHNMLPR

Download         Length: 348 bp

>AT220721 NZ_CP117256:747486-747752 [Rhizobium tumorigenes]
ATGCGGGCATCAACGCACGATGATATGAGCTGGACAGTTGCGGGAGCGAAGGCAAGGCTTTCGGAGGTGATGGAGCGCGC
GCAGTCGGCGCCTCAGACCATTACCCGCAACGGGAAGCCGAGCGTGGTGGTCGTCTCTGCCGAGGAGTGGGAGAAAAAAA
CTGCGCGTCGGGGATCGCTTGCGGAATTTCTATTGGCGTCGCCTCTGCGTGGCGCCGATCTGGACACCGAGCGGCTAAGA
GACGAGCCGCGCGACTTGTCCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References