Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 13645..14782 | Replicon | plasmid pEFS36_2 |
| Accession | NZ_CP085293 | ||
| Organism | Enterococcus faecalis strain EFS36 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | LIT96_RS15115 | Protein ID | WP_024377178.1 |
| Coordinates | 13645..14508 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | R2XCR7 |
| Locus tag | LIT96_RS15120 | Protein ID | WP_000301765.1 |
| Coordinates | 14510..14782 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LIT96_RS15080 (LIT96_15080) | 8830..9162 | - | 333 | WP_065813813.1 | CagC family type IV secretion system protein | - |
| LIT96_RS15085 (LIT96_15085) | 9186..11165 | - | 1980 | WP_227316592.1 | MobQ family relaxase | - |
| LIT96_RS15090 (LIT96_15090) | 11448..11747 | + | 300 | WP_002325624.1 | hypothetical protein | - |
| LIT96_RS15095 (LIT96_15095) | 11750..12007 | + | 258 | WP_002325623.1 | hypothetical protein | - |
| LIT96_RS15100 (LIT96_15100) | 12030..12335 | - | 306 | WP_000351790.1 | hypothetical protein | - |
| LIT96_RS15105 (LIT96_15105) | 12369..12866 | - | 498 | WP_002300565.1 | molecular chaperone DnaJ | - |
| LIT96_RS15110 (LIT96_15110) | 12886..13203 | - | 318 | WP_002338433.1 | hypothetical protein | - |
| LIT96_RS15115 (LIT96_15115) | 13645..14508 | - | 864 | WP_024377178.1 | zeta toxin family protein | Toxin |
| LIT96_RS15120 (LIT96_15120) | 14510..14782 | - | 273 | WP_000301765.1 | antitoxin | Antitoxin |
| LIT96_RS15125 (LIT96_15125) | 14799..15014 | - | 216 | WP_001835296.1 | peptide-binding protein | - |
| LIT96_RS15130 (LIT96_15130) | 15114..16010 | - | 897 | WP_024376821.1 | ParA family protein | - |
| LIT96_RS15135 (LIT96_15135) | 16113..16373 | - | 261 | Protein_22 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| LIT96_RS15140 (LIT96_15140) | 16543..17280 | - | 738 | WP_065813903.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| LIT96_RS15145 (LIT96_15145) | 17327..17566 | - | 240 | WP_002425012.1 | peptide-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | erm(B) / Cfr(D) / poxtA / fexA | - | 1..35757 | 35757 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32462.96 Da Isoelectric Point: 6.6610
>T220688 WP_024377178.1 NZ_CP085293:c14508-13645 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGI
Download Length: 864 bp
>T220688 NZ_CP117244:316716-317084 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.25 Da Isoelectric Point: 6.4676
>AT220688 WP_000301765.1 NZ_CP085293:c14782-14510 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT220688 NZ_CP117244:316498-316719 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|