Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
Location | 1217125..1218155 | Replicon | chromosome |
Accession | NZ_CP085291 | ||
Organism | Enterococcus faecalis strain EFS36 |
Toxin (Protein)
Gene name | IrrE | Uniprot ID | - |
Locus tag | LIT96_RS06090 | Protein ID | WP_227316548.1 |
Coordinates | 1217502..1218155 (+) | Length | 218 a.a. |
Antitoxin (Protein)
Gene name | ImmA | Uniprot ID | - |
Locus tag | LIT96_RS06085 | Protein ID | WP_227316547.1 |
Coordinates | 1217125..1217505 (+) | Length | 127 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LIT96_RS06065 (1214514) | 1214514..1214837 | - | 324 | WP_033628351.1 | hypothetical protein | - |
LIT96_RS06070 (1215300) | 1215300..1215704 | - | 405 | WP_221677757.1 | DUF961 family protein | - |
LIT96_RS06075 (1215704) | 1215704..1216030 | - | 327 | WP_002365226.1 | hypothetical protein | - |
LIT96_RS06080 (1216116) | 1216116..1216367 | - | 252 | WP_227316546.1 | hypothetical protein | - |
LIT96_RS06085 (1217125) | 1217125..1217505 | + | 381 | WP_227316547.1 | helix-turn-helix transcriptional regulator | Antitoxin |
LIT96_RS06090 (1217502) | 1217502..1218155 | + | 654 | WP_227316548.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
LIT96_RS06095 (1218318) | 1218318..1219049 | - | 732 | WP_227316549.1 | restriction endonuclease | - |
LIT96_RS06100 (1219467) | 1219467..1220438 | + | 972 | WP_002370644.1 | hypothetical protein | - |
LIT96_RS06105 (1220527) | 1220527..1221366 | - | 840 | WP_002370643.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 218 a.a. Molecular weight: 25828.78 Da Isoelectric Point: 6.4876
>T220672 WP_227316548.1 NZ_CP085291:1217502-1218155 [Enterococcus faecalis]
MIGLLLVDFISEKLYFEAFNLSNELIKEVAYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLRKRMLGSTSKVYNE
VIITTNKELMLERKNFTKMHEVTHYYIDIPKINSNTHTFSDMILENGYFPEDYPKEYRANVGASMLMANTQALYFALKNF
CTFEEVAQYFFMSKAALRNRLIEHLIYINNCTPCYAKSLFNDYFFNDGKKFRAIFFI
MIGLLLVDFISEKLYFEAFNLSNELIKEVAYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLRKRMLGSTSKVYNE
VIITTNKELMLERKNFTKMHEVTHYYIDIPKINSNTHTFSDMILENGYFPEDYPKEYRANVGASMLMANTQALYFALKNF
CTFEEVAQYFFMSKAALRNRLIEHLIYINNCTPCYAKSLFNDYFFNDGKKFRAIFFI
Download Length: 654 bp
>T220672 NZ_CP117238:c2041371-2041009 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
Antitoxin
Download Length: 127 a.a. Molecular weight: 14780.62 Da Isoelectric Point: 4.9215
>AT220672 WP_227316547.1 NZ_CP085291:1217125-1217505 [Enterococcus faecalis]
MKTHERIKQLRENKEITQKEISDALDINVSVYNKIELGIRPLREEELAKIADFFNVSSDYLLGRTKNPSLPSEDSNDTGQ
NIISHFRLNTSDMDVDDIEELEEELIDFQNFLIKKAKEKKRRNKKD
MKTHERIKQLRENKEITQKEISDALDINVSVYNKIELGIRPLREEELAKIADFFNVSSDYLLGRTKNPSLPSEDSNDTGQ
NIISHFRLNTSDMDVDDIEELEEELIDFQNFLIKKAKEKKRRNKKD
Download Length: 381 bp
>AT220672 NZ_CP117238:c2041538-2041368 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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