Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1217125..1218155 Replicon chromosome
Accession NZ_CP085291
Organism Enterococcus faecalis strain EFS36

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag LIT96_RS06090 Protein ID WP_227316548.1
Coordinates 1217502..1218155 (+) Length 218 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag LIT96_RS06085 Protein ID WP_227316547.1
Coordinates 1217125..1217505 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIT96_RS06065 (1214514) 1214514..1214837 - 324 WP_033628351.1 hypothetical protein -
LIT96_RS06070 (1215300) 1215300..1215704 - 405 WP_221677757.1 DUF961 family protein -
LIT96_RS06075 (1215704) 1215704..1216030 - 327 WP_002365226.1 hypothetical protein -
LIT96_RS06080 (1216116) 1216116..1216367 - 252 WP_227316546.1 hypothetical protein -
LIT96_RS06085 (1217125) 1217125..1217505 + 381 WP_227316547.1 helix-turn-helix transcriptional regulator Antitoxin
LIT96_RS06090 (1217502) 1217502..1218155 + 654 WP_227316548.1 ImmA/IrrE family metallo-endopeptidase Toxin
LIT96_RS06095 (1218318) 1218318..1219049 - 732 WP_227316549.1 restriction endonuclease -
LIT96_RS06100 (1219467) 1219467..1220438 + 972 WP_002370644.1 hypothetical protein -
LIT96_RS06105 (1220527) 1220527..1221366 - 840 WP_002370643.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(75-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-61)


Sequences

Toxin        


Download         Length: 218 a.a.        Molecular weight: 25828.78 Da        Isoelectric Point: 6.4876

>T220672 WP_227316548.1 NZ_CP085291:1217502-1218155 [Enterococcus faecalis]
MIGLLLVDFISEKLYFEAFNLSNELIKEVAYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLRKRMLGSTSKVYNE
VIITTNKELMLERKNFTKMHEVTHYYIDIPKINSNTHTFSDMILENGYFPEDYPKEYRANVGASMLMANTQALYFALKNF
CTFEEVAQYFFMSKAALRNRLIEHLIYINNCTPCYAKSLFNDYFFNDGKKFRAIFFI

Download         Length: 654 bp

>T220672 NZ_CP117238:c2041371-2041009 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14780.62 Da        Isoelectric Point: 4.9215

>AT220672 WP_227316547.1 NZ_CP085291:1217125-1217505 [Enterococcus faecalis]
MKTHERIKQLRENKEITQKEISDALDINVSVYNKIELGIRPLREEELAKIADFFNVSSDYLLGRTKNPSLPSEDSNDTGQ
NIISHFRLNTSDMDVDDIEELEEELIDFQNFLIKKAKEKKRRNKKD

Download         Length: 381 bp

>AT220672 NZ_CP117238:c2041538-2041368 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References