Detailed information of TA system TA022063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 1439086..1439626
• Replicon: chromosome
• Accession: NC_009442
• Organism: Streptococcus suis 05ZYH33

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SSU05_1500
• Protein ID: YP_001198866.1
• Coordinates: 1439086..1439346 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SSU05_1501
• Protein ID: YP_001198867.1
• Coordinates: 1439348..1439626 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSU05_1494	1434471..1434629	-	159	YP_001198860.1	hypothetical protein	-
SSU05_1495	1434665..1435699	-	1035	YP_001198861.1	hypothetical protein	-
SSU05_1496	1435689..1436864	-	1176	YP_001198862.1	permease	-
SSU05_1497	1436890..1437996	+	1107	YP_001198863.1	3-carboxymuconate cyclase	-
SSU05_1498	1438009..1438245	+	237	YP_001198864.1	hypothetical protein	-
SSU05_1499	1438278..1438931	-	654	YP_001198865.1	HAD superfamily hydrolase	-
SSU05_1500	1439086..1439346	-	261	YP_001198866.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
SSU05_1501	1439348..1439626	-	279	YP_001198867.1	hypothetical protein	Antitoxin
SSU05_1503	1439879..1441183	-	1305	YP_001198868.1	enolase	-
SSU05_1502	1441177..1441314	+	138	YP_001198869.1	hypothetical protein	-
SSU05_1504	1441656..1441790	+	135	YP_001198870.1	hypothetical protein	-
SSU05_1505	1442023..1443150	-	1128	YP_001198871.1	glycerate kinase	-
SSU05_1506	1443258..1443908	+	651	YP_001198872.1	phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1444345..1445547	1202

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (20-90)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10273.79 Da
• Isoelectric Point: 9.3944

>T22063 YP_001198866.1 NC_009442:c1439346-1439086 [Streptococcus suis 05ZYH33]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Nucleotide

• Length: 261 bp

>T22063 NC_009442:c1439346-1439086 [Streptococcus suis 05ZYH33]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10795.13 Da
• Isoelectric Point: 4.5467

>AT22063 YP_001198867.1 NC_009442:c1439626-1439348 [Streptococcus suis 05ZYH33]
MTDTLKMCYNVTQRSEVNIMSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPET
ISHADFKKELGL

Nucleotide

• Length: 279 bp

>AT22063 NC_009442:c1439626-1439348 [Streptococcus suis 05ZYH33]
TTGACAGATACTTTAAAAATGTGTTACAATGTAACACAAAGAAGCGAGGTGAATATCATGAGTACAGTGACAATCAGATT
AAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCTTTCTAGCCTTTTTAAGAAAGCTT
TGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATGAGTACAAAGCAGATCCAGAAACA
ATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG