Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2244764..2245290 | Replicon | chromosome |
| Accession | NZ_CP085202 | ||
| Organism | Shigella flexneri strain P099 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | IUX27_RS11070 | Protein ID | WP_000323025.1 |
| Coordinates | 2245003..2245290 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | IUX27_RS11065 | Protein ID | WP_000534858.1 |
| Coordinates | 2244764..2245003 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUX27_RS11040 (2240412) | 2240412..2240615 | + | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
| IUX27_RS11045 (2240651) | 2240651..2242111 | - | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| IUX27_RS11050 (2242200) | 2242200..2243219 | - | 1020 | Protein_2136 | MHS family MFS transporter YdfJ | - |
| IUX27_RS11055 (2243281) | 2243281..2244437 | + | 1157 | Protein_2137 | IS3-like element IS600 family transposase | - |
| IUX27_RS11060 (2244434) | 2244434..2244739 | - | 306 | WP_071818640.1 | hypothetical protein | - |
| IUX27_RS11065 (2244764) | 2244764..2245003 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| IUX27_RS11070 (2245003) | 2245003..2245290 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| IUX27_RS11075 (2245362) | 2245362..2245517 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| IUX27_RS11080 (2245735) | 2245735..2245986 | + | 252 | WP_000980987.1 | protein Rem | - |
| IUX27_RS11085 (2246053) | 2246053..2246331 | + | 279 | Protein_2143 | hypothetical protein | - |
| IUX27_RS11090 (2246333) | 2246333..2247382 | + | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| IUX27_RS11095 (2247395) | 2247395..2247751 | + | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| IUX27_RS11100 (2247766) | 2247766..2248587 | + | 822 | WP_000762882.1 | antitermination protein | - |
| IUX27_RS11115 (2249508) | 2249508..2249616 | + | 109 | Protein_2147 | DUF3927 family protein | - |
| IUX27_RS11120 (2249897) | 2249897..2250232 | - | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2234246..2258574 | 24328 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T220624 WP_000323025.1 NZ_CP085202:2245003-2245290 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T220624 NZ_CP117226:c80124-79708 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT220624 WP_000534858.1 NZ_CP085202:2244764-2245003 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT220624 NZ_CP117226:c80351-80121 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|