Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 940361..941015 Replicon chromosome
Accession NZ_CP085202
Organism Shigella flexneri strain P099

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag IUX27_RS04515 Protein ID WP_000244767.1
Coordinates 940608..941015 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag IUX27_RS04510 Protein ID WP_000354044.1
Coordinates 940361..940627 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUX27_RS04485 (935531) 935531..936274 + 744 WP_000951957.1 SDR family oxidoreductase -
IUX27_RS04490 (936331) 936331..937764 - 1434 Protein_862 6-phospho-beta-glucosidase BglA -
IUX27_RS04495 (937809) 937809..938119 + 311 Protein_863 N(4)-acetylcytidine aminohydrolase -
IUX27_RS04500 (938283) 938283..938942 + 660 WP_000250274.1 hemolysin III family protein -
IUX27_RS04505 (939138) 939138..940118 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
IUX27_RS04510 (940361) 940361..940627 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
IUX27_RS04515 (940608) 940608..941015 + 408 WP_000244767.1 protein YgfX Toxin
IUX27_RS04520 (941055) 941055..941576 - 522 WP_001055867.1 flavodoxin FldB -
IUX27_RS04525 (941688) 941688..942584 + 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
IUX27_RS04530 (942609) 942609..943319 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IUX27_RS04535 (943325) 943325..945058 + 1734 WP_112333882.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T220613 WP_000244767.1 NZ_CP085202:940608-941015 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T220613 NZ_CP117203:1835153-1835248 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT220613 WP_000354044.1 NZ_CP085202:940361-940627 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT220613 NZ_CP117203:c1835335-1835276 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References