Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 817846..818647 Replicon chromosome
Accession NZ_CP085202
Organism Shigella flexneri strain P099

Toxin (Protein)


Gene name yeeV Uniprot ID D3GUT5
Locus tag IUX27_RS03910 Protein ID WP_001094430.1
Coordinates 817846..818223 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D3GUT4
Locus tag IUX27_RS03915 Protein ID WP_001285620.1
Coordinates 818270..818647 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUX27_RS03880 (813059) 813059..813526 + 468 WP_171763946.1 prepilin peptidase -
IUX27_RS03890 (815195) 815195..815440 - 246 WP_000875412.1 hypothetical protein -
IUX27_RS03895 (816217) 816217..817059 - 843 WP_001290187.1 DUF4942 domain-containing protein -
IUX27_RS03900 (817144) 817144..817341 - 198 WP_000772029.1 DUF957 domain-containing protein -
IUX27_RS03905 (817361) 817361..817849 - 489 WP_000761715.1 DUF5983 family protein -
IUX27_RS03910 (817846) 817846..818223 - 378 WP_001094430.1 TA system toxin CbtA family protein Toxin
IUX27_RS03915 (818270) 818270..818647 - 378 WP_001285620.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
IUX27_RS03920 (818727) 818727..818948 - 222 WP_000692350.1 DUF987 domain-containing protein -
IUX27_RS03925 (819035) 819035..819511 - 477 WP_001387238.1 RadC family protein -
IUX27_RS03930 (819527) 819527..820000 - 474 WP_000855059.1 antirestriction protein -
IUX27_RS03935 (820342) 820342..821160 - 819 WP_001177758.1 DUF932 domain-containing protein -
IUX27_RS03940 (821339) 821339..821428 - 90 WP_112031555.1 DUF905 family protein -
IUX27_RS03945 (821571) 821571..822026 - 456 WP_005051844.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13971.82 Da        Isoelectric Point: 6.8608

>T220612 WP_001094430.1 NZ_CP085202:c818223-817846 [Shigella flexneri]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T220612 NZ_CP117203:c853013-852825 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13698.52 Da        Isoelectric Point: 5.9505

>AT220612 WP_001285620.1 NZ_CP085202:c818647-818270 [Shigella flexneri]
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp

>AT220612 NZ_CP117203:c853302-853042 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y6M7

Antitoxin

Source ID Structure
PDB 2INW
AlphaFold DB A0A0E0Y522

References