Detailed information of TA system TA022061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/-
• Location: 926585..927693
• Replicon: chromosome
• Accession: NC_009442
• Organism: Streptococcus suis 05ZYH33

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: -
• Locus tag: SSU05_0955
• Protein ID: YP_001198321.1
• Coordinates: 926824..927693 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: SSU05_0954
• Protein ID: YP_001198320.1
• Coordinates: 926585..926809 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSU05_0949	922525..923637	-	1113	YP_001198315.1	lantibiotic modifying enzyme	-
SSU05_0950	923737..923856	+	120	YP_001198316.1	hypothetical protein	-
SSU05_0951	923964..924461	+	498	YP_001198317.1	DNA recombinase	-
SSU05_0952	924462..924878	+	417	YP_001198318.1	recombinase	-
SSU05_0953	924880..926442	+	1563	YP_001198319.1	DNA recombinase	-
SSU05_0954	926585..926809	+	225	YP_001198320.1	hypothetical protein	Antitoxin
SSU05_0955	926824..927693	+	870	YP_001198321.1	hypothetical protein	Toxin
SSU05_0956	927674..928408	+	735	YP_001198322.1	hypothetical protein	-
SSU05_0957	928441..929304	+	864	YP_001198323.1	aminoglycoside 6-adenylyltansferase	-
SSU05_0958	929348..929875	+	528	YP_001198324.1	adenine phosphoribosyltransferase	-
SSU05_0959	930103..931422	+	1320	YP_001198325.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	ant(6)-Ia	-	928441..931422	2981

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32926.57 Da
• Isoelectric Point: 4.8781

>T22061 YP_001198321.1 NC_009442:926824-927693 [Streptococcus suis 05ZYH33]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T22061 NC_009442:926824-927693 [Streptococcus suis 05ZYH33]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATCGTATTAGGGGGCTC
ACGTGCAAGAGGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAATTGGATGATAAAAATAGAAACAACCTTGTTGTGCCTCCCGGAGCGTGGGGTGATTGG
ATTAATGGCGGCGGATGGTTATTTATAAATGGGTATCATGTTGACTTGATTTTACGTGATATAAAACGGGTAGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCAATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGTAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGATATGACCGAGAAACTTTATAAAGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT22061 YP_001198320.1 NC_009442:926585-926809 [Streptococcus suis 05ZYH33]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT22061 NC_009442:926585-926809 [Streptococcus suis 05ZYH33]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCCATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGAAGAAATAAAAATATCTAACGAATAA