Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 137717..138453 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP085198 | ||
| Organism | Klebsiella quasipneumoniae strain NDM-101 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | L7SZ15 |
| Locus tag | LH783_RS25895 | Protein ID | WP_003026803.1 |
| Coordinates | 137717..138199 (-) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | L7SZ29 |
| Locus tag | LH783_RS25900 | Protein ID | WP_003026799.1 |
| Coordinates | 138187..138453 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LH783_RS25875 (LH783_25910) | 133013..133717 | - | 705 | WP_031591821.1 | toll/interleukin-1 receptor domain-containing protein | - |
| LH783_RS25880 (LH783_25915) | 133877..135223 | - | 1347 | WP_094311841.1 | ISNCY family transposase | - |
| LH783_RS25885 (LH783_25920) | 135452..136084 | + | 633 | WP_001567369.1 | hypothetical protein | - |
| LH783_RS25890 (LH783_25925) | 136113..137516 | - | 1404 | WP_001272054.1 | ISNCY-like element ISKpn21 family transposase | - |
| LH783_RS25895 (LH783_25930) | 137717..138199 | - | 483 | WP_003026803.1 | GNAT family N-acetyltransferase | Toxin |
| LH783_RS25900 (LH783_25935) | 138187..138453 | - | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin |
| LH783_RS25905 (LH783_25940) | 138863..139831 | - | 969 | WP_072202995.1 | IS5 family transposase | - |
| LH783_RS25910 (LH783_25945) | 139891..140373 | + | 483 | WP_004205976.1 | helix-turn-helix domain-containing protein | - |
| LH783_RS25915 (LH783_25950) | 140409..141107 | - | 699 | WP_004205977.1 | urea ABC transporter ATP-binding subunit UrtE | - |
| LH783_RS25920 (LH783_25955) | 141117..141914 | - | 798 | WP_004205978.1 | urea ABC transporter ATP-binding protein UrtD | - |
| LH783_RS25925 (LH783_25960) | 141914..142987 | - | 1074 | WP_017900354.1 | urea ABC transporter permease subunit UrtC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..183890 | 183890 | |
| - | inside | IScluster/Tn | - | - | 133877..139831 | 5954 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17353.97 Da Isoelectric Point: 9.5822
>T220609 WP_003026803.1 NZ_CP085198:c138199-137717 [Klebsiella quasipneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
Download Length: 483 bp
>T220609 NZ_CP117201:24240-24815 [Pantoea sp. SS70]
ATGAGTTCTGGCTATACCGTCATATTTGACGCCTGTGTACTCTATCCTGCACCTCTGCGCAGCTTCCTGATGTACCTTGC
TGCCGGCGGACAGTTTCGCGCGAGATGGACGGAAGACATACACGAAGAGTGGATCCGGAACGTGCTGCTCAACCGCACCG
AACTGAACCTGGCTCAGCTTCAGCGGGTCCGTGCCTTAATGGATCGCCACGTGCCCGATGCTCTCGTCACCGGATATCAG
TCTCTGACAGACTCCATCCGGGGATTGCCTGATAAAGACGATCGTCACGTTGTCGCTGCGGCAATCGTTGCCCGGGCTGA
AGGCATTGTCACATTTAACCTGAAAGATTTTCCTGACGACGTTCTCGCGACATGGAATCTGCGGGCCATTCATCCAGACA
GCTTTATTACAGATCTGACCGAACTGGACATTACCCTGGTACTGGATGCCGCGCGCCGCCAGCGCGCCAGCCTGAAATCA
CCTCCATTCACTCCTGACGAATTTCTGGACTGCCTGCTGCGCCAGCAGCTGCCGGAAACCGTTTCACGCCTGCGTCCCCT
GACGGCACTGATTTAA
ATGAGTTCTGGCTATACCGTCATATTTGACGCCTGTGTACTCTATCCTGCACCTCTGCGCAGCTTCCTGATGTACCTTGC
TGCCGGCGGACAGTTTCGCGCGAGATGGACGGAAGACATACACGAAGAGTGGATCCGGAACGTGCTGCTCAACCGCACCG
AACTGAACCTGGCTCAGCTTCAGCGGGTCCGTGCCTTAATGGATCGCCACGTGCCCGATGCTCTCGTCACCGGATATCAG
TCTCTGACAGACTCCATCCGGGGATTGCCTGATAAAGACGATCGTCACGTTGTCGCTGCGGCAATCGTTGCCCGGGCTGA
AGGCATTGTCACATTTAACCTGAAAGATTTTCCTGACGACGTTCTCGCGACATGGAATCTGCGGGCCATTCATCCAGACA
GCTTTATTACAGATCTGACCGAACTGGACATTACCCTGGTACTGGATGCCGCGCGCCGCCAGCGCGCCAGCCTGAAATCA
CCTCCATTCACTCCTGACGAATTTCTGGACTGCCTGCTGCGCCAGCAGCTGCCGGAAACCGTTTCACGCCTGCGTCCCCT
GACGGCACTGATTTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10147.59 Da Isoelectric Point: 4.5256
>AT220609 WP_003026799.1 NZ_CP085198:c138453-138187 [Klebsiella quasipneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
Download Length: 267 bp
>AT220609 NZ_CP117201:23785-24243 [Pantoea sp. SS70]
ATGACACAACTTCAGAATAAGCTTCCTTCCCTGCAGGAAGCGGAACTTGCGCGCCTGTGTAGCCGGGAGCTCTCCGCCGT
CCTTGAAACACGGGCAGAGTCTCAGCAGGTTTCACTCACTGACAGAAGTGGCCGGATCCACAATGTCAGCATTCCGGTCA
GCGCGCTTCGTATGCTGGTTGACGTGCTGACCGAACTCGGGGACGGGAACGCCGTGCGCCTTGTTCCGGTAGGGGCCGAA
ATGACTACGCAGGAGGTGGCCGACCTTTTGAACATTTCGCGTCCAACGCTGATTCGGCTTCTGGACAACGGTGAACTGCC
TTATCACCGCACGGGAAACCGCCGTAAAATCCGCTATATGGATGCGCTGGCCTACCGTGAAAAACTGGTGAACCAGAGGC
ATGATGCACTTGATGAGCTGGGTGCGCTCGATCAGGAACTGGGGCTGGGATACGAATGA
ATGACACAACTTCAGAATAAGCTTCCTTCCCTGCAGGAAGCGGAACTTGCGCGCCTGTGTAGCCGGGAGCTCTCCGCCGT
CCTTGAAACACGGGCAGAGTCTCAGCAGGTTTCACTCACTGACAGAAGTGGCCGGATCCACAATGTCAGCATTCCGGTCA
GCGCGCTTCGTATGCTGGTTGACGTGCTGACCGAACTCGGGGACGGGAACGCCGTGCGCCTTGTTCCGGTAGGGGCCGAA
ATGACTACGCAGGAGGTGGCCGACCTTTTGAACATTTCGCGTCCAACGCTGATTCGGCTTCTGGACAACGGTGAACTGCC
TTATCACCGCACGGGAAACCGCCGTAAAATCCGCTATATGGATGCGCTGGCCTACCGTGAAAAACTGGTGAACCAGAGGC
ATGATGCACTTGATGAGCTGGGTGCGCTCGATCAGGAACTGGGGCTGGGATACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0J2GNW6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Q8YL66 |