Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 17451..18094 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP085198 | ||
| Organism | Klebsiella quasipneumoniae strain NDM-101 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | LH783_RS25245 | Protein ID | WP_021312475.1 |
| Coordinates | 17451..17867 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A6B7Q5S4 |
| Locus tag | LH783_RS25250 | Protein ID | WP_021312476.1 |
| Coordinates | 17864..18094 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LH783_RS25195 (LH783_25225) | 12927..13181 | - | 255 | WP_032731922.1 | hypothetical protein | - |
| LH783_RS25200 (LH783_25230) | 13371..14339 | + | 969 | WP_101991433.1 | IS5-like element IS903 family transposase | - |
| LH783_RS25205 (LH783_25235) | 14395..14580 | - | 186 | Protein_15 | hypothetical protein | - |
| LH783_RS25210 (LH783_25240) | 14629..14832 | - | 204 | WP_004150739.1 | HHA domain-containing protein | - |
| LH783_RS25215 (LH783_25245) | 14893..15387 | - | 495 | WP_016528789.1 | hypothetical protein | - |
| LH783_RS25220 (LH783_25250) | 15418..15984 | - | 567 | WP_009654312.1 | hypothetical protein | - |
| LH783_RS25225 (LH783_25255) | 15981..16244 | - | 264 | WP_004118691.1 | hypothetical protein | - |
| LH783_RS25230 (LH783_25260) | 16484..16810 | - | 327 | WP_124989605.1 | hypothetical protein | - |
| LH783_RS25235 (LH783_25265) | 16889..17107 | - | 219 | WP_021312527.1 | hypothetical protein | - |
| LH783_RS25240 (LH783_25270) | 17171..17416 | - | 246 | WP_065905238.1 | hypothetical protein | - |
| LH783_RS25245 (LH783_25275) | 17451..17867 | - | 417 | WP_021312475.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LH783_RS25250 (LH783_25280) | 17864..18094 | - | 231 | WP_021312476.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LH783_RS25255 (LH783_25285) | 18699..18992 | + | 294 | WP_124989603.1 | hypothetical protein | - |
| LH783_RS25260 (LH783_25290) | 19041..19514 | + | 474 | WP_065905236.1 | hypothetical protein | - |
| LH783_RS25265 (LH783_25295) | 19516..20484 | + | 969 | WP_078207718.1 | IS5 family transposase | - |
| LH783_RS25270 (LH783_25300) | 21171..21971 | - | 801 | WP_065905270.1 | EAL domain-containing protein | - |
| LH783_RS25275 (LH783_25305) | 22023..22751 | - | 729 | Protein_29 | CSS-motif domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..183890 | 183890 | |
| - | flank | IS/Tn | - | - | 19516..20484 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15033.44 Da Isoelectric Point: 7.8915
>T220608 WP_021312475.1 NZ_CP085198:c17867-17451 [Klebsiella quasipneumoniae]
VKKTFMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVN
VKKTFMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVN
Download Length: 417 bp
>T220608 NZ_CP117200:407127-407471 [Pantoea sp. SS70]
ATGCACGCGACATTTATTGAGCTGTCCAGCTTTCAGAAGTACCGGGTGGAATACCTGAGCGATGATCAGTTTAGGCTTTT
CCAGAATATGTTGATGGCCGACCCTGAAAAGGGCGACGTGATCCCAGATACGGGCGGCCTGCGTAAAGTCCGGTTCAGGG
ATGAGCGTCGAAACAAGGGCACAAGAGGCGGCATTAGGGTTATCTATTACTGGACGAACGAAAAAGGCCAGTTCATCCTG
TTTACCATTTACGATAAGGATCAACGCGACGATCTGACCAAACAGCAGCGCGACGCCTTGGGTTCGGCGCTGAACGTGAT
TAAAAAGGGGCTGAGACATGACTGA
ATGCACGCGACATTTATTGAGCTGTCCAGCTTTCAGAAGTACCGGGTGGAATACCTGAGCGATGATCAGTTTAGGCTTTT
CCAGAATATGTTGATGGCCGACCCTGAAAAGGGCGACGTGATCCCAGATACGGGCGGCCTGCGTAAAGTCCGGTTCAGGG
ATGAGCGTCGAAACAAGGGCACAAGAGGCGGCATTAGGGTTATCTATTACTGGACGAACGAAAAAGGCCAGTTCATCCTG
TTTACCATTTACGATAAGGATCAACGCGACGATCTGACCAAACAGCAGCGCGACGCCTTGGGTTCGGCGCTGAACGTGAT
TAAAAAGGGGCTGAGACATGACTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8723.76 Da Isoelectric Point: 4.3410
>AT220608 WP_021312476.1 NZ_CP085198:c18094-17864 [Klebsiella quasipneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDL
Download Length: 231 bp
>AT220608 NZ_CP117200:407464-407778 [Pantoea sp. SS70]
ATGACTGAACGCGATATTTTTAGTGAGCTGATGACGGGAATGCAGGAGCTGAAACATCATAAGGACGGAAAAATCACGCT
CAAGACCTACAAGGTCAGCAAGCGCGCGCCCGTCACCATCGCGCCACAGGAGCTGCGTGATGTACGCGAAAAACTTAACC
TTTCTCAGGCCGTTTTTGCGCACTACCTTCACACAGGTGAAACCACCTATCAAAACTGGGAGCAAGGCAGGTCCAGGCCT
AACGCCCAGGCTGTTTTGCTTATACGCATGGTTCAGCAGAATCCTGAAACCTTGAAAACGCTCGCACAGCTTTAA
ATGACTGAACGCGATATTTTTAGTGAGCTGATGACGGGAATGCAGGAGCTGAAACATCATAAGGACGGAAAAATCACGCT
CAAGACCTACAAGGTCAGCAAGCGCGCGCCCGTCACCATCGCGCCACAGGAGCTGCGTGATGTACGCGAAAAACTTAACC
TTTCTCAGGCCGTTTTTGCGCACTACCTTCACACAGGTGAAACCACCTATCAAAACTGGGAGCAAGGCAGGTCCAGGCCT
AACGCCCAGGCTGTTTTGCTTATACGCATGGTTCAGCAGAATCCTGAAACCTTGAAAACGCTCGCACAGCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|