Detailed information of TA system TA220596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 97222..97735
• Replicon: chromosome
• Accession: NZ_CP085197
• Organism: Klebsiella quasipneumoniae strain NDM-101

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LH783_RS00395
• Protein ID: WP_064190102.1
• Coordinates: 97222..97503 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: LH783_RS00400
• Protein ID: WP_002886901.1
• Coordinates: 97493..97735 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH783_RS00380 (92264)	92264..93919	+	1656	WP_064178460.1	alpha,alpha-phosphotrehalase	-
LH783_RS00385 (94305)	94305..96443	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
LH783_RS00390 (96754)	96754..97218	+	465	WP_064190101.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LH783_RS00395 (97222)	97222..97503	-	282	WP_064190102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LH783_RS00400 (97493)	97493..97735	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LH783_RS00405 (97813)	97813..99723	-	1911	WP_057212387.1	PRD domain-containing protein	-
LH783_RS00410 (99746)	99746..100897	-	1152	WP_065878155.1	lactonase family protein	-
LH783_RS00415 (100964)	100964..101704	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11031.81 Da
• Isoelectric Point: 10.1752

>T220596 WP_064190102.1 NZ_CP085197:c97503-97222 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T220596 NZ_CP117199:389820-389996 [Pantoea sp. SS70]
TTGAGCAGCAGGGAGCTGATCAGGATGTTGCTTGAGCGAGGTTGGGTATTAGATCGTGTTAAGGGAAGCCATCATGTATT
CGTAAGAAGGGACAAGCCCTACCATATTTCGCTTCCTCATCCTGAGAAAGACCTGGCAACTGGAACAGTACGTAAGCTAA
TTAAGTTAATGGACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT220596 WP_002886901.1 NZ_CP085197:c97735-97493 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT220596 NZ_CP117199:390109-390513 [Pantoea sp. SS70]
ATGAGATTCCCCGTTTATCTTCATAAGACAGAAAGCAACACCTATTCTGGCTTTGTACCGGACGTTGTTGGATGTTTTTT
TGCTGGCGAGACAGTGGATGATGCATTAACCGATGCTTCTGCTGCGATTGATTCGCATGTTGAGTCGTCGACTGATGCGG
GTTACGAGGTGCCGGTGGCAACGAACATTGAAACGCATATTGAGGATGAAAATTGTCAGGGTGGTTATTGGGCCTTTGTC
GATATCGATCTCAGTCGCTATGAAGGCAAAGCAGTAAAGCTCAACATCACCTTGCCGCAGAATCTGTTAACTAAAATTGA
TAGCTATGTCGATCACCATCGTGAATATGGTTCCAGAAGCGGTTTTTTGGCCGCGTTAGCGCGCAAAGAATTGGCAAACG
CCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0