Detailed information of TA system TA022059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 859140..859617
• Replicon: chromosome
• Accession: NC_009442
• Organism: Streptococcus suis 05ZYH33

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SSU05_0886
• Protein ID: YP_001198252.1
• Coordinates: 859140..859397 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SSU05_0887
• Protein ID: YP_001198253.1
• Coordinates: 859381..859617 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSU05_0881	854771..855844	+	1074	YP_001198247.1	site-specific tyrosine recombinase XerS	-
SSU05_0882	855914..857422	-	1509	YP_001198248.1	phosphomannomutase	-
SSU05_0883	857475..858440	-	966	YP_001198249.1	Signal transduction histidine kinase	-
SSU05_0884	858437..858889	-	453	YP_001198250.1	response regulator	-
SSU05_0885	858886..859110	-	225	YP_001198251.1	response regulator	-
SSU05_0886	859140..859397	-	258	YP_001198252.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
SSU05_0887	859381..859617	-	237	YP_001198253.1	hypothetical protein	Antitoxin
SSU05_0888	859754..860854	-	1101	YP_001198254.1	peptide ABC transporter permease	-
SSU05_0889	861109..861285	-	177	YP_001198255.1	peptide ABC transporter permease	-
SSU05_0890	861285..861698	-	414	YP_001198256.1	peptide ABC transporter permease	-
SSU05_0891	861699..862451	-	753	YP_001198257.1	peptide ABC transporter ATPase	-
SSU05_0892	862587..863321	-	735	YP_001198258.1	bacteroiocin operon protein	-
SSU05_0893	863323..864069	-	747	YP_001198259.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	795955..882167	86212

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-75)

Antitoxin

• Protein of unknown function DUF6290 (2-70)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9981.62 Da
• Isoelectric Point: 10.8924

>T22059 YP_001198252.1 NC_009442:c859397-859140 [Streptococcus suis 05ZYH33]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Nucleotide

• Length: 258 bp

>T22059 NC_009442:c859397-859140 [Streptococcus suis 05ZYH33]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8856.01 Da
• Isoelectric Point: 3.7666

>AT22059 YP_001198253.1 NC_009442:c859617-859381 [Streptococcus suis 05ZYH33]
MKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDEDLL

Nucleotide

• Length: 237 bp

>AT22059 NC_009442:c859617-859381 [Streptococcus suis 05ZYH33]
TTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTTGTCAGAACTCATTCG
GACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTGAATACGAGGCAGACT
TGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAAGACCTGTTATAA