Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4385636..4386434 Replicon chromosome
Accession NZ_CP085188
Organism Escherichia coli strain EC195

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag LIN52_RS21315 Protein ID WP_000854735.1
Coordinates 4386057..4386434 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag LIN52_RS21310 Protein ID WP_032153712.1
Coordinates 4385636..4386010 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN52_RS21275 (4381369) 4381369..4382253 + 885 WP_024166630.1 50S ribosome-binding GTPase -
LIN52_RS21280 (4382372) 4382372..4383049 + 678 WP_023155728.1 hypothetical protein -
LIN52_RS21285 (4383079) 4383079..4383288 + 210 WP_023155727.1 DUF905 family protein -
LIN52_RS21290 (4383379) 4383379..4384197 + 819 WP_001234693.1 DUF932 domain-containing protein -
LIN52_RS21295 (4384289) 4384289..4384774 + 486 WP_032153711.1 antirestriction protein -
LIN52_RS21300 (4384790) 4384790..4385266 + 477 WP_001186715.1 RadC family protein -
LIN52_RS21305 (4385335) 4385335..4385556 + 222 WP_000692345.1 DUF987 domain-containing protein -
LIN52_RS21310 (4385636) 4385636..4386010 + 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LIN52_RS21315 (4386057) 4386057..4386434 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
LIN52_RS21320 (4386431) 4386431..4386922 + 492 WP_023155722.1 DUF5983 family protein -
LIN52_RS21325 (4386934) 4386934..4387131 + 198 WP_000839265.1 DUF957 domain-containing protein -
LIN52_RS21330 (4387216) 4387216..4388082 + 867 WP_032153714.1 DUF4942 domain-containing protein -
LIN52_RS21335 (4388154) 4388154..4388417 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
LIN52_RS21340 (4388414) 4388414..4388740 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
LIN52_RS21345 (4389623) 4389623..4391161 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - papC / papD 4315841..4398974 83133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T220586 WP_000854735.1 NZ_CP085188:4386057-4386434 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T220586 NZ_CP117184:c4585526-4585041 [Salmonella enterica subsp. enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT220586 WP_032153712.1 NZ_CP085188:4385636-4386010 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT220586 NZ_CP117184:c4585801-4585514 [Salmonella enterica subsp. enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References