Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2887831..2888675 Replicon chromosome
Accession NZ_CP085188
Organism Escherichia coli strain EC195

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag LIN52_RS14075 Protein ID WP_000854686.1
Coordinates 2887831..2888214 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag LIN52_RS14080 Protein ID WP_001285602.1
Coordinates 2888295..2888675 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN52_RS14035 (2882834) 2882834..2883325 - 492 WP_001297187.1 DUF1097 domain-containing protein -
LIN52_RS14040 (2883427) 2883427..2883981 - 555 WP_001001902.1 molecular chaperone YcdY -
LIN52_RS14045 (2884005) 2884005..2884742 - 738 WP_000283664.1 zinc-binding phosphatase -
LIN52_RS14050 (2884797) 2884797..2885735 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
LIN52_RS14060 (2886206) 2886206..2887047 - 842 Protein_2754 DUF4942 domain-containing protein -
LIN52_RS14065 (2887132) 2887132..2887329 - 198 WP_000839253.1 DUF957 domain-containing protein -
LIN52_RS14070 (2887346) 2887346..2887834 - 489 WP_032180032.1 DUF5983 family protein -
LIN52_RS14075 (2887831) 2887831..2888214 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
LIN52_RS14080 (2888295) 2888295..2888675 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LIN52_RS14085 (2888686) 2888686..2889369 - 684 WP_000086768.1 hypothetical protein -
LIN52_RS14090 (2889388) 2889388..2889609 - 222 WP_000692298.1 DUF987 domain-containing protein -
LIN52_RS14095 (2889672) 2889672..2890148 - 477 WP_001186726.1 RadC family protein -
LIN52_RS14100 (2890164) 2890164..2890649 - 486 WP_000214307.1 antirestriction protein -
LIN52_RS14105 (2890741) 2890741..2891562 - 822 WP_001761104.1 DUF932 domain-containing protein -
LIN52_RS14110 (2891663) 2891663..2891871 - 209 Protein_2764 DUF905 domain-containing protein -
LIN52_RS14115 (2891972) 2891972..2892427 - 456 WP_000581506.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCMY-2 csgB / csgD / csgE / csgF / csgG 2879216..2935182 55966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T220583 WP_000854686.1 NZ_CP085188:c2888214-2887831 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T220583 NZ_CP117184:c3873129-3872716 [Salmonella enterica subsp. enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT220583 WP_001285602.1 NZ_CP085188:c2888675-2888295 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT220583 NZ_CP117184:c3873376-3873110 [Salmonella enterica subsp. enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References