Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1869186..1870018 Replicon chromosome
Accession NZ_CP085188
Organism Escherichia coli strain EC195

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0Q2Y5N3
Locus tag LIN52_RS08980 Protein ID WP_001514886.1
Coordinates 1869186..1869560 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag LIN52_RS08985 Protein ID WP_001360327.1
Coordinates 1869650..1870018 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN52_RS08945 (1864702) 1864702..1865175 + 474 WP_001105385.1 DNA gyrase inhibitor SbmC -
LIN52_RS08950 (1865374) 1865374..1866432 + 1059 WP_032181141.1 FUSC family protein -
LIN52_RS08955 (1866604) 1866604..1866933 + 330 WP_000450409.1 DUF496 family protein -
LIN52_RS08960 (1867034) 1867034..1867300 - 267 WP_063121129.1 EutP/PduV family microcompartment system protein -
LIN52_RS08965 (1867670) 1867670..1868041 - 372 WP_001295631.1 IS110 family transposase -
LIN52_RS08970 (1868857) 1868857..1868937 - 81 Protein_1753 hypothetical protein -
LIN52_RS08975 (1869037) 1869037..1869189 - 153 Protein_1754 DUF5983 family protein -
LIN52_RS08980 (1869186) 1869186..1869560 - 375 WP_001514886.1 TA system toxin CbtA family protein Toxin
LIN52_RS08985 (1869650) 1869650..1870018 - 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LIN52_RS08990 (1870181) 1870181..1870402 - 222 WP_000692345.1 DUF987 domain-containing protein -
LIN52_RS08995 (1870465) 1870465..1870941 - 477 WP_001186747.1 RadC family protein -
LIN52_RS09000 (1870957) 1870957..1871430 - 474 WP_000855059.1 antirestriction protein -
LIN52_RS09005 (1871772) 1871772..1872590 - 819 WP_088540043.1 DUF932 domain-containing protein -
LIN52_RS09010 (1872708) 1872708..1872903 - 196 Protein_1761 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.91 Da        Isoelectric Point: 7.2909

>T220573 WP_001514886.1 NZ_CP085188:c1869560-1869186 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T220573 NZ_CP117182:c1292801-1292055 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCGGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGAAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACTGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT220573 WP_001360327.1 NZ_CP085188:c1870018-1869650 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT220573 NZ_CP117182:c1292054-1291884 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAGA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q2Y5N3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References