Detailed information of TA system TA022057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 4145833..4146401
• Replicon: chromosome
• Accession: NC_009439
• Organism: Pseudomonas mendocina ymp

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: PMEN_RS23715
• Protein ID: WP_012019693.1
• Coordinates: 4146120..4146401 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: PMEN_RS18920
• Protein ID: WP_012019692.1
• Coordinates: 4145833..4146123 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PMEN_RS18895 (Pmen_3756)	4141127..4141741	-	615	WP_012019687.1	type I-E CRISPR-associated protein Cas6/Cse3/CasE	-
PMEN_RS18900 (Pmen_3757)	4141716..4142378	-	663	WP_012019688.1	type I-E CRISPR-associated protein Cas5/CasD	-
PMEN_RS18905 (Pmen_3758)	4142381..4143535	-	1155	WP_012019689.1	type I-E CRISPR-associated protein Cas7/Cse4/CasC	-
PMEN_RS18910 (Pmen_3759)	4143546..4144088	-	543	WP_012019690.1	type I-E CRISPR-associated protein Cse2/CasB	-
PMEN_RS18915 (Pmen_3760)	4144085..4145626	-	1542	WP_041772965.1	type I-E CRISPR-associated protein Cse1/CasA	-
PMEN_RS18920 (Pmen_3761)	4145833..4146123	+	291	WP_012019692.1	hypothetical protein	Antitoxin
PMEN_RS23715 (Pmen_3762)	4146120..4146401	+	282	WP_012019693.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
PMEN_RS18930 (Pmen_3763)	4146404..4149061	-	2658	WP_012019694.1	CRISPR-associated helicase/endonuclease Cas3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10530.13 Da
• Isoelectric Point: 10.1507

>T22057 WP_012019693.1 NC_009439:4146120-4146401 [Pseudomonas mendocina ymp]
VRLAWTRLALNDRKAIRSYIAQDNPMAALALDELFAEKASRLADHPGLGRAGRVSGTRELVVHQHYLMIYDLANDQVRIL
RVLHTARLWPSAD

Nucleotide

• Length: 282 bp

>T22057 NC_009439:4146120-4146401 [Pseudomonas mendocina ymp]
GTGAGGCTGGCCTGGACGCGTCTCGCGCTAAATGACCGCAAGGCCATCCGCAGCTATATCGCCCAGGACAATCCAATGGC
CGCCCTGGCGCTGGATGAGCTGTTCGCGGAGAAGGCCAGCCGCCTGGCCGATCATCCAGGCTTGGGACGAGCAGGCCGCG
TAAGCGGTACTCGCGAGCTGGTCGTACACCAGCATTATCTGATGATCTACGACCTGGCCAATGATCAGGTGCGCATCCTC
CGCGTACTGCATACAGCCCGCCTGTGGCCAAGTGCAGACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10898.08 Da
• Isoelectric Point: 4.7370

>AT22057 WP_012019692.1 NC_009439:4145833-4146123 [Pseudomonas mendocina ymp]
MSEATFTFRVDEALKSEFAQAAKARDRTGAQLLRDFMRDFVRQQQEAAEHDAWLRRQVQMGLDSANAGELLSSEEVEAEA
AAWRAEMRRKMDSSAS

Nucleotide

• Length: 291 bp

>AT22057 NC_009439:4145833-4146123 [Pseudomonas mendocina ymp]
ATGAGTGAAGCCACCTTTACCTTCCGCGTCGACGAAGCGCTGAAGAGCGAATTTGCTCAAGCCGCCAAAGCGCGTGACCG
CACCGGTGCCCAACTGCTGCGTGACTTCATGCGTGATTTTGTGCGGCAACAGCAAGAAGCCGCCGAGCACGACGCCTGGC
TGCGCCGCCAGGTGCAAATGGGGCTGGATTCGGCCAATGCTGGTGAGCTGCTCAGTAGCGAAGAGGTCGAAGCGGAAGCT
GCCGCATGGCGCGCTGAAATGCGGCGCAAGATGGACAGCTCCGCGTCGTGA