Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 903580..904234 Replicon chromosome
Accession NZ_CP085188
Organism Escherichia coli strain EC195

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag LIN52_RS04445 Protein ID WP_000244777.1
Coordinates 903827..904234 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LIN52_RS04440 Protein ID WP_000354046.1
Coordinates 903580..903846 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN52_RS04415 (898868) 898868..899611 + 744 Protein_865 SDR family oxidoreductase -
LIN52_RS04420 (899668) 899668..901101 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
LIN52_RS04425 (901146) 901146..901457 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
LIN52_RS04430 (901621) 901621..902280 + 660 WP_000250274.1 hemolysin III family protein -
LIN52_RS04435 (902357) 902357..903337 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LIN52_RS04440 (903580) 903580..903846 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LIN52_RS04445 (903827) 903827..904234 + 408 WP_000244777.1 protein YgfX Toxin
LIN52_RS04450 (904274) 904274..904795 - 522 WP_001055874.1 flavodoxin FldB -
LIN52_RS04455 (904907) 904907..905803 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LIN52_RS04460 (905828) 905828..906538 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LIN52_RS04465 (906544) 906544..908277 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T220568 WP_000244777.1 NZ_CP085188:903827-904234 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T220568 NZ_CP117181:c2750543-2750016 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGCTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT220568 WP_000354046.1 NZ_CP085188:903580-903846 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT220568 NZ_CP117181:c2750830-2750540 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCGGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References