Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 54604..55126 | Replicon | plasmid pEC7518-63k |
| Accession | NZ_CP085185 | ||
| Organism | Escherichia coli strain EC7518 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | LIN51_RS24890 | Protein ID | WP_000638823.1 |
| Coordinates | 54604..54885 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | LIN51_RS24895 | Protein ID | WP_000121741.1 |
| Coordinates | 54875..55126 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LIN51_RS24855 (LIN51_24855) | 50753..51073 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| LIN51_RS24860 (LIN51_24860) | 51144..51434 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| LIN51_RS24865 (LIN51_24865) | 51434..52018 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| LIN51_RS24870 (LIN51_24870) | 52039..52437 | - | 399 | WP_072643816.1 | hypothetical protein | - |
| LIN51_RS24875 (LIN51_24875) | 52556..52993 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| LIN51_RS24880 (LIN51_24880) | 52999..54234 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| LIN51_RS24885 (LIN51_24885) | 54237..54536 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| LIN51_RS24890 (LIN51_24890) | 54604..54885 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LIN51_RS24895 (LIN51_24895) | 54875..55126 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| LIN51_RS24900 (LIN51_24900) | 55226..55861 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| LIN51_RS24905 (LIN51_24905) | 55934..56221 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| LIN51_RS24910 (LIN51_24910) | 56234..56488 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| LIN51_RS24915 (LIN51_24915) | 56490..57131 | - | 642 | WP_227311782.1 | type IV secretion system protein | - |
| LIN51_RS24920 (LIN51_24920) | 57137..58132 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| LIN51_RS24925 (LIN51_24925) | 58136..58393 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| LIN51_RS24930 (LIN51_24930) | 58390..58692 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| LIN51_RS24935 (LIN51_24935) | 58673..58930 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| LIN51_RS24940 (LIN51_24940) | 58963..59409 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| LIN51_RS24945 (LIN51_24945) | 59420..59590 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| LIN51_RS24950 (LIN51_24950) | 59594..60037 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..63359 | 63359 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T220557 WP_000638823.1 NZ_CP085185:c54885-54604 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T220557 NZ_CP117181:500853-501059 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATTCCCGAACTGCATCTTAAGGGCGACTGGCTGGCCGAGGCGGGATTTGAGACCGGGACGAGCGTAACCGTGAAGATCTC
GGAGGGGTGTTTGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCTGGTGAAAAAGTCGA
TGAAGCATATTAAGGCGGGGGTAAATAATGTGGTGAACAGGGATTAA
ATTCCCGAACTGCATCTTAAGGGCGACTGGCTGGCCGAGGCGGGATTTGAGACCGGGACGAGCGTAACCGTGAAGATCTC
GGAGGGGTGTTTGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCTGGTGAAAAAGTCGA
TGAAGCATATTAAGGCGGGGGTAAATAATGTGGTGAACAGGGATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT220557 WP_000121741.1 NZ_CP085185:c55126-54875 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT220557 NZ_CP117181:c501049-500864 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|