Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 33628..34426 Replicon plasmid pEC7518-111k
Accession NZ_CP085184
Organism Escherichia coli strain EC7518

Toxin (Protein)


Gene name ataT Uniprot ID E2QDF3
Locus tag LIN51_RS24125 Protein ID WP_000072677.1
Coordinates 33905..34426 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A0V9R6Q7
Locus tag LIN51_RS24120 Protein ID WP_001351987.1
Coordinates 33628..33897 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN51_RS24100 (LIN51_24100) 29617..30357 - 741 WP_001755535.1 hypothetical protein -
LIN51_RS24105 (LIN51_24105) 30536..32230 - 1695 WP_000443723.1 hypothetical protein -
LIN51_RS24110 (LIN51_24110) 32282..32635 - 354 WP_160378290.1 hypothetical protein -
LIN51_RS24115 (LIN51_24115) 32641..33309 - 669 WP_000161228.1 division plane positioning ATPase MipZ -
LIN51_RS24120 (LIN51_24120) 33628..33897 + 270 WP_001351987.1 DUF1778 domain-containing protein Antitoxin
LIN51_RS24125 (LIN51_24125) 33905..34426 + 522 WP_000072677.1 GNAT family N-acetyltransferase Toxin
LIN51_RS24130 (LIN51_24130) 34595..34846 - 252 WP_000901559.1 hypothetical protein -
LIN51_RS24135 (LIN51_24135) 34848..35540 - 693 WP_000856757.1 hypothetical protein -
LIN51_RS24140 (LIN51_24140) 35554..35877 - 324 WP_001717323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111696 111696


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19392.17 Da        Isoelectric Point: 8.6369

>T220555 WP_000072677.1 NZ_CP085184:33905-34426 [Escherichia coli]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLANHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

>T220555 NZ_CP117181:492223-492468 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTACAAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10082.54 Da        Isoelectric Point: 7.0155

>AT220555 WP_001351987.1 NZ_CP085184:33628-33897 [Escherichia coli]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLNEESWNLVMDAISNPPAPNDKLKR
AADRLKSME

Download         Length: 270 bp

>AT220555 NZ_CP117181:c492373-492066 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9R6P3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9R6Q7

References