Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4360752..4361347 Replicon chromosome
Accession NZ_CP085183
Organism Escherichia coli strain EC7518

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LIN51_RS21195 Protein ID WP_000239579.1
Coordinates 4360752..4361102 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LIN51_RS21200 Protein ID WP_001223208.1
Coordinates 4361096..4361347 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN51_RS21175 (4356028) 4356028..4357050 - 1023 WP_001296689.1 ABC transporter permease -
LIN51_RS21180 (4357064) 4357064..4358566 - 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
LIN51_RS21185 (4358876) 4358876..4359832 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LIN51_RS21190 (4360142) 4360142..4360672 + 531 WP_000055072.1 inorganic diphosphatase -
LIN51_RS21195 (4360752) 4360752..4361102 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LIN51_RS21200 (4361096) 4361096..4361347 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LIN51_RS21205 (4361559) 4361559..4361900 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LIN51_RS21210 (4361903) 4361903..4365682 - 3780 WP_000060895.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T220552 WP_000239579.1 NZ_CP085183:c4361102-4360752 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T220552 NZ_CP117170:6440-6754 [Serratia proteamaculans]
ATGCAATTCACCGTTTACCAGAATACCGGAAAGACAACGATTTACCCGTACCTGCTTGACGTGACGAGCGATATTATCGG
ACAGCTCAATCGTCGGATCGTCATCCCCTTACTCCCGCTCGAAAAGTACCCCACCGGAAAACGGCCTGAACGGATGATCC
CTATCGTCATGCTGACAGACGGCAACGAATACGCCGTAATGACTCATGAACTGGCAAGCATACCCGTTCGGGCGCTGGGC
GCTGAGTTCTGTACTGCCGTGCAATATCGTTCTCAGGTTAAAGCCTCGATAGATTTTCTTTTGGACGGGATTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT220552 WP_001223208.1 NZ_CP085183:c4361347-4361096 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT220552 NZ_CP117170:6201-6437 [Serratia proteamaculans]
ATGGCAACGAAACAACGGAACACACAAAGCGTCACCATGACGCTTGAGCGCGGCTTGCTGAACCAGGCACGTGAAGCGGG
TATCAACCTTAGCGCAACTCTGGTTGCAGCCCTTGATGCTGAATTACGCCGTTATGCTGCTCAGAAGTGGCAAAAAGAGA
ACATGGAGGCCCTGGACGCCTTAAATCGCTTTCACGATGAGAATGGTTGTTTCAGCGATGAATACAGGACGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References