Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 1180935..1181596 Replicon chromosome
Accession NC_009439
Organism Pseudomonas mendocina ymp

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PMEN_RS05225 Protein ID WP_011921114.1
Coordinates 1180935..1181354 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8I0VLZ4
Locus tag PMEN_RS05230 Protein ID WP_011921115.1
Coordinates 1181351..1181596 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMEN_RS05195 (Pmen_1039) 1177587..1178498 + 912 WP_011921109.1 DMT family transporter -
PMEN_RS05200 (Pmen_1040) 1178600..1179178 + 579 WP_003244654.1 hypothetical protein -
PMEN_RS05205 (Pmen_1041) 1179187..1179633 - 447 WP_011921110.1 hypothetical protein -
PMEN_RS24035 (Pmen_1042) 1179660..1179824 - 165 WP_011921111.1 hypothetical protein -
PMEN_RS05210 (Pmen_1043) 1179963..1180316 + 354 WP_041772814.1 excalibur calcium-binding domain-containing protein -
PMEN_RS05215 (Pmen_1044) 1180313..1180540 - 228 WP_011921113.1 hypothetical protein -
PMEN_RS05225 (Pmen_1045) 1180935..1181354 - 420 WP_011921114.1 type II toxin-antitoxin system VapC family toxin Toxin
PMEN_RS05230 (Pmen_1046) 1181351..1181596 - 246 WP_011921115.1 Arc family DNA-binding protein Antitoxin
PMEN_RS23450 (Pmen_1047) 1181649..1181900 - 252 Protein_1051 tyrosine-type recombinase/integrase -
PMEN_RS23845 1182668..1183081 + 414 WP_157045641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(13-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15011.23 Da        Isoelectric Point: 4.2058

>T22055 WP_011921114.1 NC_009439:c1181354-1180935 [Pseudomonas mendocina ymp]
MILLDTNVLSELMRAKPAPQVLEWVDAQPVGDLVITSITVAEILYGIAKMPDGKRKQGLLDVASVMFDEDFAGNILPFDA
DAAVHYAEIAAETEAKGQVVDMADAQIAAIGRLHDAVIATRNIRHFETLGVALVDPWSN

Download         Length: 420 bp

>T22055 NC_009439:c1181354-1180935 [Pseudomonas mendocina ymp]
ATGATCCTGCTTGATACCAACGTGCTGTCGGAACTCATGCGTGCCAAGCCTGCGCCTCAGGTTCTGGAGTGGGTTGACGC
TCAGCCTGTCGGGGATCTGGTAATCACCTCGATCACCGTTGCGGAAATTCTCTATGGCATTGCCAAGATGCCGGACGGGA
AACGCAAGCAGGGACTGCTCGATGTAGCCTCGGTCATGTTCGATGAAGACTTCGCGGGCAATATCCTGCCGTTCGATGCA
GATGCCGCTGTGCATTACGCAGAGATAGCCGCAGAAACCGAGGCTAAAGGGCAGGTGGTTGATATGGCCGATGCGCAGAT
CGCTGCAATCGGTCGGCTACATGATGCCGTGATCGCAACTCGCAATATTCGCCACTTCGAAACGCTAGGCGTTGCCCTGG
TAGATCCCTGGAGCAATTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8990.24 Da        Isoelectric Point: 10.7217

>AT22055 WP_011921115.1 NC_009439:c1181596-1181351 [Pseudomonas mendocina ymp]
MAAITIRNLDDDLKAQLRIVAASHGRSMEEEVRFIIRQALSRQEKRGGLGSRIHSRFAAVGGADLELPERKTKARAASFD
E

Download         Length: 246 bp

>AT22055 NC_009439:c1181596-1181351 [Pseudomonas mendocina ymp]
ATGGCCGCCATCACTATTCGAAACCTCGACGACGACTTGAAAGCCCAGCTGCGTATTGTCGCTGCTAGCCACGGTCGCTC
CATGGAAGAAGAGGTCAGGTTCATCATTCGGCAGGCTCTGTCACGTCAAGAAAAGCGTGGCGGCTTGGGCAGTCGTATTC
ACTCCCGCTTTGCCGCTGTCGGTGGGGCTGACCTTGAGCTGCCAGAACGCAAAACCAAAGCCCGGGCAGCGAGCTTTGAT
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References