Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3605551..3606169 Replicon chromosome
Accession NZ_CP085183
Organism Escherichia coli strain EC7518

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LIN51_RS17550 Protein ID WP_001291435.1
Coordinates 3605951..3606169 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LIN51_RS17545 Protein ID WP_000344800.1
Coordinates 3605551..3605925 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN51_RS17535 (3600640) 3600640..3601833 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LIN51_RS17540 (3601856) 3601856..3605005 + 3150 WP_227311690.1 efflux RND transporter permease AcrB -
LIN51_RS17545 (3605551) 3605551..3605925 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LIN51_RS17550 (3605951) 3605951..3606169 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LIN51_RS17555 (3606340) 3606340..3606891 + 552 WP_000102564.1 maltose O-acetyltransferase -
LIN51_RS17560 (3607007) 3607007..3607477 + 471 WP_000136192.1 YlaC family protein -
LIN51_RS17565 (3607641) 3607641..3609191 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LIN51_RS17570 (3609233) 3609233..3609586 - 354 WP_000878141.1 DUF1428 family protein -
LIN51_RS17580 (3609965) 3609965..3610276 + 312 WP_000409911.1 MGMT family protein -
LIN51_RS17585 (3610307) 3610307..3610879 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T220548 WP_001291435.1 NZ_CP085183:3605951-3606169 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T220548 NZ_CP117168:c4160173-4159904 [Serratia proteamaculans]
ATGCGGATAGAATGGAGCAGTGAGGCTCAGGAAGAGCTATGGAGCATTATTGATTATATCGATGACAGAAACCCGCAGGC
GGCGCGAAAATTGCACCGGGAAATCGAAGCGGTGGTCCTTACCCTGCCGTTAAACCCTTTAATGTACCGCTTGGGTAGGG
TGGATAATACGCGAGAAATTGTCGTCCATCCCAACTATCTGGTTGTTTATAGAGTCATCGGACATATAGAAGTTCTGAGT
GTTATTCATGCCAAACGTGAATATCCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT220548 WP_000344800.1 NZ_CP085183:3605551-3605925 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT220548 NZ_CP117168:c4160371-4160177 [Serratia proteamaculans]
ATGGCGATAAAACCTCCACTCTCCACTTTGCCGGTGCTGGGCTCGGCTGAGCAAACAGAGAGTTACGATCGTTGGTACCG
GGCCAAGGTTGAGAGCGCAATTAACAGTGAACAACCGAGAATTTCACACGAACAAGTGATGACTGAAATGCAAACTCGTC
TAGCGGCAAAGAAAAAATTGCGCAAAATGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References